Peter O Fedichev
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Explore the profile of Peter O Fedichev including associated specialties, affiliations and a list of published articles.
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20
Citations
452
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Recent Articles
11.
Shindyapina A, Zenin A, Tarkhov A, Santesmasses D, Fedichev P, Gladyshev V
Elife
. 2020 Apr;
9.
PMID: 32254024
Heritability of human lifespan is 23-33% as evident from twin studies. Genome-wide association studies explored this question by linking particular alleles to lifespan traits. However, genetic variants identified so far...
12.
Burmistrova O, Olias-Arjona A, Lapresa R, Jimenez-Blasco D, Eremeeva T, Shishov D, et al.
Sci Rep
. 2019 Aug;
9(1):11670.
PMID: 31406177
The glycolytic rate in neurons is low in order to allow glucose to be metabolized through the pentose-phosphate pathway (PPP), which regenerates NADPH to preserve the glutathione redox status and...
13.
Tarkhov A, Alla R, Ayyadevara S, Pyatnitskiy M, Menshikov L, Shmookler Reis R, et al.
Sci Rep
. 2019 May;
9(1):7368.
PMID: 31089188
We collected 60 age-dependent transcriptomes for C. elegans strains including four exceptionally long-lived mutants (mean adult lifespan extended 2.2- to 9.4-fold) and three examples of lifespan-increasing RNAi treatments. Principal Component...
14.
Zenin A, Tsepilov Y, Sharapov S, Getmantsev E, Menshikov L, Fedichev P, et al.
Commun Biol
. 2019 Feb;
2:41.
PMID: 30729179
Aging populations face diminishing quality of life due to increased disease and morbidity. These challenges call for longevity research to focus on understanding the pathways controlling healthspan. We use the...
15.
Fedichev P
Front Genet
. 2018 Nov;
9:483.
PMID: 30405692
Age is the most important single factor associated with chronic diseases and ultimately, death. The mortality rate in humans doubles approximately every eight years, as described by the Gompertz law...
16.
Pyrkov T, Getmantsev E, Zhurov B, Avchaciov K, Pyatnitskiy M, Menshikov L, et al.
Aging (Albany NY)
. 2018 Oct;
10(10):2973-2990.
PMID: 30362959
We performed a systematic evaluation of the relationships between locomotor activity and signatures of frailty, morbidity, and mortality risks using physical activity records from the 2003-2006 National Health and Nutrition...
17.
Pyrkov T, Slipensky K, Barg M, Kondrashin A, Zhurov B, Zenin A, et al.
Sci Rep
. 2018 Mar;
8(1):5210.
PMID: 29581467
Age-related physiological changes in humans are linearly associated with age. Naturally, linear combinations of physiological measures trained to estimate chronological age have recently emerged as a practical way to quantify...
18.
Tarkhov A, Menshikov L, Fedichev P
J Theor Biol
. 2017 Jan;
416:180-189.
PMID: 28093294
Gompertz empirical law of mortality is often used in practical research to parametrize survival fraction as a function of age with the help of just two quantities: the Initial Mortality...
19.
Pyrkov T, Sevostyanova I, Schmalhausen E, Shkoporov A, Vinnik A, Muronetz V, et al.
ChemMedChem
. 2013 Jul;
8(8):1322-9.
PMID: 23813838
Glycolysis lies at the basis of metabolism and cell energy supply. The disregulation of glycolysis is involved in such pathological processes as cancer proliferation, neurodegenerative diseases, and amplification of ischemic...
20.
Joce C, Stahl J, Shridhar M, Hutchinson M, Watkins L, Fedichev P, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(18):5411-3.
PMID: 20709548
Increasing numbers of target protein structures available for computational studies makes the structure-based screening paradigm more attractive for initial hit indentification. We have developed a novel in silico screening methodology...