Peter McGuirk
Overview
Explore the profile of Peter McGuirk including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
881
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0
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Recent Articles
1.
Flis E, Barber G, Nulty C, Keogh B, McGuirk P, Anand A, et al.
Cancers (Basel)
. 2021 Apr;
13(9).
PMID: 33922955
Chronic inflammation plays an important role in the pathogenesis of oesophageal adenocarcinoma (EAC) and its only known precursor, Barrett's oesophagus (BE). Recent studies have shown that oesophageal TLR2 levels increase...
2.
McDonald C, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, et al.
Brain Behav Immun
. 2016 Jul;
58:191-200.
PMID: 27422717
The effects of Toll-like receptor (TLR) activation in peripheral cells are well characterized but, although several TLRs are expressed on cells of the brain, the consequences of their activation on...
3.
Arslan F, Houtgraaf J, Keogh B, Kazemi K, De Jong R, McCormack W, et al.
Circ Cardiovasc Interv
. 2012 Feb;
5(2):279-87.
PMID: 22354933
Background: Toll-like receptor (TLR)-2 is an important mediator of innate immunity and ischemia/reperfusion-induced cardiac injury. We have previously shown that TLR2 inhibition reduces infarct size and improves cardiac function in...
4.
Ultaigh S, Saber T, McCormick J, Connolly M, Dellacasagrande J, Keogh B, et al.
Arthritis Res Ther
. 2011 Feb;
13(1):R33.
PMID: 21345222
Introduction: The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells. Methods: RA synovial tissue biopsies, obtained under...
5.
McGuirk P, Higgins S, Mills K
Curr Allergy Asthma Rep
. 2010 Apr;
10(1):21-8.
PMID: 20425510
The role of distinct CD4(+) T-cell populations in regulating the nature and strength of immune responses is well documented and in the past has principally focused on the cross-regulation of...
6.
Arslan F, Smeets M, ONeill L, Keogh B, McGuirk P, Timmers L, et al.
Circulation
. 2009 Dec;
121(1):80-90.
PMID: 20026776
Background: Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR signaling may optimize reperfusion therapy and enhance cell survival and...
7.
Braat H, McGuirk P, Ten Kate F, Huibregtse I, Dunne P, Hommes D, et al.
Gut
. 2006 Sep;
56(3):351-7.
PMID: 16952913
Background: Filamentous haemagglutinin (FHA) of Bordetella pertussis subverts host immune responses by inhibiting interleukin (IL)12 and enhancing IL10 production by macrophages and dendritic cells, and promoting the induction of regulatory...
8.
Guarner F, Bourdet-Sicard R, Brandtzaeg P, Gill H, McGuirk P, van Eden W, et al.
Nat Clin Pract Gastroenterol Hepatol
. 2006 May;
3(5):275-84.
PMID: 16673007
In industrialized countries the incidence of diseases caused by immune dysregulation has risen. Epidemiologic studies initially suggested this was connected to a reduction in the incidence of infectious diseases; however,...
9.
McGuirk P, Higgins S, Mills K
Curr Allergy Asthma Rep
. 2005 Jan;
5(1):51-5.
PMID: 15659263
The role of distinct CD4+ T-cell populations in regulating the nature and strength of immune responses is well documented, and has in the past principally focused on the mutual antagonism...
10.
Byrne P, McGuirk P, Todryk S, Mills K
Eur J Immunol
. 2004 Aug;
34(9):2579-88.
PMID: 15307190
IFN-gamma plays a critical role in protection against Bordetella pertussis, but Th1 cells are only detectable after the infection has started to resolve, suggesting a protective role for innate IFN-gamma...