Peter Keov
Overview
Explore the profile of Peter Keov including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
330
Followers
0
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Recent Articles
1.
Peng C, Vecchio E, Nguyen A, De Seram M, Tang R, Keov P, et al.
Br J Pharmacol
. 2024 Aug;
181(22):4677-4692.
PMID: 39154373
Background: There is increasing interest in developing FPR2 agonists (compound 43, ACT-389949 and BMS-986235) as potential pro-resolving therapeutics, with ACT-389949 and BMS-986235 having entered phase I clinical development. FPR2 activation...
2.
Tomasevic N, Emser F, Muratspahic E, Gattringer J, Hasinger S, Hellinger R, et al.
J Biol Chem
. 2024 Apr;
300(6):107330.
PMID: 38679329
The cannabinoid type 2 receptor (CBR), a G protein-coupled receptor, is an important regulator of immune cell function and a promising target to treat chronic inflammation and fibrosis. While CBR...
3.
Keov P, Christopoulos G, Hick C, Glendorf T, Ballarin-Gonzalez B, Wootten D, et al.
Mol Pharmacol
. 2024 Mar;
105(5):359-373.
PMID: 38458773
Dual amylin and calcitonin receptor agonists (DACRAs) show promise as efficacious therapeutics for treatment of metabolic disease, including obesity. However, differences in efficacy in vivo have been observed for individual...
4.
Ham S, Mukaida S, Sato M, Keov P, Bengtsson T, Furness S, et al.
Pharmacol Res Perspect
. 2024 Feb;
12(1):e1176.
PMID: 38332691
Truncation of the C-terminal tail of the β -AR, transfection of βARKct or over-expression of a kinase-dead GRK mutant reduces isoprenaline-stimulated glucose uptake, indicating that GRK is important for this...
5.
Dekan Z, Kremsmayr T, Keov P, Godin M, Teakle N, Durrauer L, et al.
Chem Sci
. 2021 Jun;
12(11):4057-4062.
PMID: 34163676
Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental physiological functions four G protein-coupled receptors, VR, VR, VR, and OTR. Ligand development remains challenging for these receptors due...
6.
Fletcher M, Keov P, Truong T, Mennen G, Hick C, Zhao P, et al.
J Pharmacol Exp Ther
. 2021 Mar;
377(3):417-440.
PMID: 33727283
Obesity and associated comorbidities are a major health burden, and novel therapeutics to help treat obesity are urgently needed. There is increasing evidence that targeting the amylin receptors (AMYRs), heterodimers...
7.
Ngo T, Wilkins B, So S, Keov P, Chahal K, Finch A, et al.
Nat Chem Biol
. 2021 Mar;
17(4):383-386.
PMID: 33649602
No abstract available.
8.
Duerrauer L, Muratspahic E, Gattringer J, Keov P, Mendel H, Pfleger K, et al.
Sci Rep
. 2019 Dec;
9(1):19295.
PMID: 31848378
The neuropeptides oxytocin (OT) and vasopressin (VP) and their G protein-coupled receptors OTR, VR, VR, and VR form an important and widely-distributed neuroendocrine signaling system. In mammals, this signaling system...
9.
Baratchi S, Keov P, Darby W, Lai A, Khoshmanesh K, Thurgood P, et al.
Front Pharmacol
. 2019 Feb;
10:6.
PMID: 30728775
TRPV4 is a non-selective cation channel that tunes the function of different tissues including the vascular endothelium, lung, chondrocytes, and neurons. GSK1016790A is the selective and potent agonist of TRPV4...
10.
Keov P, Liutkeviciute Z, Hellinger R, Clark R, Gruber C
Sci Rep
. 2018 Jul;
8(1):10020.
PMID: 29968789
The oxytocin/vasopressin signalling system is conserved across the animal kingdom. In insects, the role of oxytocin-type (inotocin) neuropeptides has only been studied in locusts, beetles and ants, but their physiology...