Peter Jeffs
Overview
Explore the profile of Peter Jeffs including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
64
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Recent Articles
1.
Lin Z, Falkinham 3rd J, Tawfik K, Jeffs P, Bray B, Dubay G, et al.
J Nat Prod
. 2012 Sep;
75(9):1518-23.
PMID: 22988812
Burkholdines are cyclic lipopeptides with unusual antifungal potency, making them promising leads as a new class of antifungal agents. However, a recent report using knockout mutagenesis indicates that these and...
2.
Tawfik K, Jeffs P, Bray B, Dubay G, Falkinham J, Mesbah M, et al.
Org Lett
. 2010 Jan;
12(4):664-6.
PMID: 20085289
Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine,...
3.
Lu R, Tucker J, Pickens J, Ma Y, Zinevitch T, Kirichenko O, et al.
J Med Chem
. 2009 Jun;
52(14):4481-7.
PMID: 19534463
Previously disclosed HIV (human immunodeficiency virus) attachment inhibitors, exemplified by BMS 806 (formally BMS378806, 1), are characterized by a substituted indole or azaindole ring linked to a benzoylpiperazine via a...
4.
Lu R, Tucker J, Zinevitch T, Kirichenko O, Konoplev V, Kuznetsova S, et al.
J Med Chem
. 2007 Dec;
50(26):6535-44.
PMID: 18052117
The crystal structures of many tertiary alpha-ketoamides reveal an orthogonal arrangement of the two carbonyl groups. Based on the hypothesis that the alpha-ketoamide HIV attachment inhibitor BMS 806 (formally BMS378806,...