» Articles » PMID: 20085289

Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia Ambifaria 2.2N

Overview
Journal Org Lett
Specialties Biochemistry
Chemistry
Date 2010 Jan 21
PMID 20085289
Citations 23
Authors
Affiliations
Soon will be listed here.
Abstract

Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.

Citing Articles

Natural and engineered xylosyl products from microbial source.

Qi J, Kang S, Zhao L, Gao J, Liu C Nat Prod Bioprospect. 2024; 14(1):13.

PMID: 38296905 PMC: 10830979. DOI: 10.1007/s13659-024-00435-1.


Natural Polyketides Act as Promising Antifungal Agents.

Wang L, Lu H, Jiang Y Biomolecules. 2023; 13(11).

PMID: 38002254 PMC: 10669366. DOI: 10.3390/biom13111572.


Compilation of the Antimicrobial Compounds Produced by Sensu Stricto.

Rodriguez-Cisneros M, Morales-Ruiz L, Salazar-Gomez A, Rojas-Rojas F, Estrada-de Los Santos P Molecules. 2023; 28(4).

PMID: 36838633 PMC: 9958762. DOI: 10.3390/molecules28041646.


Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides.

Clements-Decker T, Kode M, Khan S, Khan W Front Chem. 2022; 10:1025979.

PMID: 36277345 PMC: 9581180. DOI: 10.3389/fchem.2022.1025979.


The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues.

Konno H, Sasaki M, Sano H, Osawa K, Nosaka K, Yano S Molecules. 2022; 27(4).

PMID: 35208979 PMC: 8877233. DOI: 10.3390/molecules27041191.