Peter J Oates
Overview
Explore the profile of Peter J Oates including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
29
Citations
734
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Miyamoto S, Zhang G, Hall D, Oates P, Maity S, Madesh M, et al.
J Biol Chem
. 2020 Apr;
295(21):7249-7260.
PMID: 32277051
Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial...
2.
Kador P, Wyman M, Oates P
Prog Retin Eye Res
. 2016 Apr;
54:1-29.
PMID: 27102270
Diabetes mellitus (DM) is a major health problem with devastating effects on ocular health in both industrialized and developing countries. The control of hyperglycemia is critical to minimizing the impact...
3.
Oates P
Curr Opin Investig Drugs
. 2010 Mar;
11(4):402-17.
PMID: 20336588
Diabetic kidney disease, or diabetic nephropathy, is the leading cause of kidney failure in developed countries and is projected to place an increasingly heavy burden on medical, social and economic...
4.
Xie P, Sun L, Oates P, Srivastava S, Kanwar Y
Am J Physiol Renal Physiol
. 2010 Mar;
298(6):F1393-404.
PMID: 20335317
Renal-specific oxido-reductase/myoinositol oxygenase (RSOR/MIOX) is expressed in renal tubules. It catabolizes myo-inositol and its expression is increased in diabetic mice and in LLC-PK(1) cells under high-glucose ambience. Aldose reductase (AR)...
5.
Landau Z, Novotny M, Preston G, Wright K, Freeman T, Dai H, et al.
J Clin Pharmacol
. 2010 Mar;
50(5):521-30.
PMID: 20220044
Increased glucose flux through the polyol pathway and the resultant oxidative stress is thought to be a major mechanistic contributor to microvascular diabetic complications. Inhibition of flux through this pathway...
6.
Ido Y, Nyengaard J, Chang K, Tilton R, Kilo C, Mylari B, et al.
Antioxid Redox Signal
. 2009 Jul;
12(1):39-51.
PMID: 19624259
These experiments were undertaken to assess the importance of cytoplasmic (c) sorbitol oxidation versus mitochondrial (m) pyruvate oxidation in mediating neural and vascular dysfunction attributable to hyperglycemia in diabetic rats....
7.
Pfefferkorn J, Lou J, Minich M, Filipski K, He M, Zhou R, et al.
Bioorg Med Chem Lett
. 2009 May;
19(12):3247-52.
PMID: 19435665
A promising area of novel anti-diabetic therapy involves identification of small molecule activators of the glucokinase enzyme to reduce blood glucose and normalize glucose stimulated insulin secretion. Herein, we report...
8.
Li Q, Hwang Y, Ananthakrishnan R, Oates P, Guberski D, Ramasamy R
Cardiovasc Diabetol
. 2008 Oct;
7:33.
PMID: 18957123
We investigated the role of polyol pathway enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH) in mediating injury due to ischemia-reperfusion (IR) in Type 2 diabetic BBZ rat hearts. Specifically,...
9.
Qiu L, Wu X, Chau J, Szeto I, Tam W, Guo Z, et al.
J Biol Chem
. 2008 May;
283(25):17175-83.
PMID: 18445591
Aldose reductase (AR) is implicated in the development of a number of diabetic complications, but the underlying mechanisms remain to be fully elucidated. We performed this study to determine whether...
10.
Yang B, Hodgkinson A, Oates P, Millward B, Demaine A
Biochim Biophys Acta
. 2008 Mar;
1782(5):295-302.
PMID: 18325349
The aim of this study was to investigate whether high glucose induces aldose reductase (AKR1B1) expression through NFkappaB, which may contribute to the pathogenesis of diabetic nephropathy. 34 Caucasoid patients...