Peter J McGuire
Overview
Explore the profile of Peter J McGuire including associated specialties, affiliations and a list of published articles.
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39
Citations
1169
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Recent Articles
1.
Tarasenko T, Warren E, Fuchs A, Singh B, Marin J, Szibor M, et al.
Res Sq
. 2024 Sep;
PMID: 39315267
T cell activation, proliferation, and differentiation are fundamentally driven by shifts in cellular metabolism, with mitochondria playing a central role. Cytochrome c oxidase (COX, complex IV) is a key player...
2.
VanPortfliet J, Lei Y, Ramanathan M, Martinez C, Wong J, Stodola T, et al.
bioRxiv
. 2024 May;
PMID: 38798587
Mitochondrial diseases (MtD) represent a significant public health challenge due to their heterogenous clinical presentation, often severe and progressive symptoms, and lack of effective therapies. Environmental exposures, such bacterial and...
3.
Gordon-Lipkin E, Banerjee P, Marin Franco J, Tarasenko T, Kruk S, Thompson E, et al.
Front Immunol
. 2023 Jul;
14:1142634.
PMID: 37483601
Introduction: The majority of studies on oxidative phosphorylation in immune cells have been performed in mouse models, necessitating human translation. To understand the impact of oxidative phosphorylation (OXPHOS) deficiency on...
4.
Warren E, Gordon-Lipkin E, Cheung F, Chen J, Mukherjee A, Apps R, et al.
J Transl Med
. 2023 May;
21(1):331.
PMID: 37208779
Background: People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction may cause chronic inflammation,...
5.
Gordon-Lipkin E, Banerjee P, Thompson E, Kruk S, Marin Franco J, McGuire P
Mol Genet Metab
. 2023 Apr;
139(2):107581.
PMID: 37104980
Introduction: Immunometabolic studies in mice have suggested the importance of oxidative phosphorylation (OXPHOS) in humoral immunity. However, there are important distinctions between murine and human immunity. Furthermore, translational studies on...
6.
Warren E, Gordon-Lipkin E, Cheung F, Chen J, Mukherjee A, Apps R, et al.
Res Sq
. 2023 Mar;
PMID: 36909538
People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction may cause chronic inflammation, which...
7.
Tarasenko T, Banerjee P, Gomez-Rodriguez J, Gildea D, Zhang S, Wolfsberg T, et al.
Res Sq
. 2023 Feb;
PMID: 36789409
Background: Modulation of metabolic flux through pyruvate dehydrogenase complex (PDC) plays an important role in T cell activation and differentiation. PDC sits at the transition between glycolysis and the tricarboxylic...
8.
Xu Q, Milanez-Almeida P, Martins A, Radtke A, Hoehn K, Oguz C, et al.
Nat Immunol
. 2022 Dec;
24(1):186-199.
PMID: 36536106
Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which may not fully reflect immune responses at the site of infection. Using samples from 110 children undergoing...
9.
Gordon-Lipkin E, Marcum C, Kruk S, Thompson E, Kelly S, Kalish H, et al.
Clin Transl Med
. 2022 Nov;
12(11):e1100.
PMID: 36336785
Background: Viral infection is a major cause of morbidity in children with mitochondrial disease (MtD). As a result, families with children with MtD are highly adherent to risk mitigation behaviours...
10.
Gordon-Lipkin E, Marcum C, Kruk S, Thompson E, Yeske P, Martin L, et al.
Res Dev Disabil
. 2022 Oct;
131:104346.
PMID: 36201931
Background: Children with developmental disabilities are vulnerable to morbidity associated with COVID-19. Aims: To understand attitudes toward routine childhood vaccinations versus the COVID-19 vaccine in a population of families affected...