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Peter J Hamilton

Explore the profile of Peter J Hamilton including associated specialties, affiliations and a list of published articles. Areas
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Articles 45
Citations 1406
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Recent Articles
1.
Truby N, Smith C, Hamilton P
bioRxiv . 2025 Feb; PMID: 39896556
Transposable elements (TEs) are repetitive DNA sequences capable of being transcribed and reintegrated, or transposed, into distinct loci throughout the genome. While thought to be largely transcriptionally silenced in brain,...
2.
Picone J, Hassan A, Kim R, Lira D, Silva G, Truby N, et al.
Mol Psychiatry . 2024 Nov; PMID: 39587295
Distinguishing the brain mechanisms affected by distinct addictive drugs may inform targeted therapies against specific substance use disorders (SUDs). Here, we explore the function of a drug-associated, transcriptionally repressive transcription...
3.
Guerin A, Spolding B, Bozaoglu K, Swinton C, Liu Z, Panizzutti Parry B, et al.
Dialogues Clin Neurosci . 2024 Oct; 26(1):64-76. PMID: 39394974
Introduction: Assessing candidate gene sequence variations and expression helps to understand methamphetamine use disorder and inform potential treatments. We investigated single nucleotide polymorphisms (SNPs) and gene expression in four candidate...
4.
Martinez-Rivera F, Yim Y, Godino A, Minier-Toribio A, Tofani S, Holt L, et al.
bioRxiv . 2024 Jul; PMID: 39026727
The development of drug addiction is characterized by molecular changes in brain reward regions that lead to the transition from recreational to compulsive drug use. These neurobiological processes in brain...
5.
Heller E, Hamilton P
Methods Mol Biol . 2024 Jul; 2842:309-321. PMID: 39012603
Modern neuroscience research is increasingly discovering that alterations in epigenetic states within key brain cells is correlated with brain diseases. These epigenetic alterations may include changes in histone post-translational modifications...
6.
Hamilton P, Lim C, Nestler E, Heller E
Methods Mol Biol . 2024 Jul; 2842:129-152. PMID: 39012593
Epigenetic regulation is intrinsic to basic neurobiological function as well as neurological disease. Regulation of chromatin-modifying enzymes in the brain is critical during both development and adulthood and in response...
7.
Kim R, Truby N, Silva G, Picone J, Miller C, Baldwin A, et al.
Transl Psychiatry . 2024 Jun; 14(1):239. PMID: 38834575
Prior research has identified differential protein expression levels of linker histone H1x within the ventral hippocampus (vHipp) of stress-susceptible versus stress-resilient mice. These mice are behaviorally classified based on their...
8.
Parise E, Gyles T, Godino A, Sial O, Browne C, Parise L, et al.
bioRxiv . 2024 Apr; PMID: 38659771
Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these...
9.
Truby N, Kim R, Silva G, Qu X, Picone J, Alemu R, et al.
Transl Psychiatry . 2024 Jan; 14(1):59. PMID: 38272911
The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function of ZFP189, a transcription factor whose expression and function in rodent...
10.
Kim R, Truby N, Silva G, Picone J, Miller C, Neve R, et al.
bioRxiv . 2023 Nov; PMID: 37986938
Prior research has identified differential protein expression levels of linker histone H1x within the ventral hippocampus (vHipp) of stress-susceptible versus stress-resilient mice. These mice are behaviorally classified based on their...