Zachary S Lorsch
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Explore the profile of Zachary S Lorsch including associated specialties, affiliations and a list of published articles.
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18
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1579
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Recent Articles
1.
Parise E, Gyles T, Godino A, Sial O, Browne C, Parise L, et al.
bioRxiv
. 2024 Apr;
PMID: 38659771
Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these...
2.
Layne S, Lorsch Z, Patel A
Dig Dis Sci
. 2023 Apr;
68(6):2226-2236.
PMID: 37071244
In our present clinical paradigm, patient symptoms and presentation in the setting of traditional findings from endoscopy (erosive esophagitis, Barrett's esophagus, reflux-mediated stenosis), esophageal high-resolution manometry, and/or ambulatory reflux monitoring...
3.
Teague C, Picone J, Wright W, Browne C, Silva G, Futamura R, et al.
Biol Psychiatry
. 2022 Oct;
93(6):502-511.
PMID: 36253194
Background: Over the course of chronic drug use, brain transcriptional neuroadaptation is thought to contribute to a change in drug use behavior over time. The function of the transcription factor...
4.
Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress
Lorsch Z, Ambesi-Impiombato A, Zenowich R, Morganstern I, Leahy E, Bansal M, et al.
Biol Psychiatry
. 2020 Dec;
89(9):920-928.
PMID: 33309017
Background: The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral...
5.
Hamilton P, Chen E, Tolstikov V, Pena C, Picone J, Shah P, et al.
Sci Rep
. 2020 Oct;
10(1):18134.
PMID: 33093530
Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the...
6.
Issler O, Van der Zee Y, Ramakrishnan A, Wang J, Tan C, Loh Y, et al.
Neuron
. 2020 Apr;
106(6):912-926.e5.
PMID: 32304628
Depression is a common disorder that affects women at twice the rate of men. Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts, represent...
7.
Lorsch Z, Hamilton P, Ramakrishnan A, Parise E, Salery M, Wright W, et al.
Nat Neurosci
. 2019 Aug;
22(9):1413-1423.
PMID: 31427770
Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to...
8.
Walker D, Cates H, Loh Y, Purushothaman I, Ramakrishnan A, Cahill K, et al.
Biol Psychiatry
. 2018 Jun;
84(12):867-880.
PMID: 29861096
Background: Global changes in gene expression underlying circuit and behavioral dysregulation associated with cocaine addiction remain incompletely understood. Here, we show how a history of cocaine self-administration (SA) reprograms transcriptome-wide...
9.
Labonte B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, et al.
Nat Med
. 2018 Apr;
24(4):525.
PMID: 29634684
This corrects the article DOI: 10.1038/nm.4386.
10.
Lorsch Z, Loh Y, Purushothaman I, Walker D, Parise E, Salery M, et al.
Nat Commun
. 2018 Mar;
9(1):1116.
PMID: 29549264
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process...