Peter J Cavnar
Overview
Explore the profile of Peter J Cavnar including associated specialties, affiliations and a list of published articles.
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7
Citations
382
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0
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Recent Articles
1.
Swain C, Robbs E, Verma L, Brandt H, Seppaenen A, Cavnar P
PLoS One
. 2025 Feb;
20(2):e0318878.
PMID: 39937830
Atypical antipsychotics are widely used for the treatment of mental and behavioral disorders such as bipolar disorder, obsessive-compulsive disorder, and schizophrenia. However, these drugs can occasionally induce neutropenia or agranulocytosis,...
2.
Auld N, Flood K, Kesharwani T, Cavnar P
Phosphorus Sulfur Silicon Relat Elem
. 2023 Mar;
197(8):876-884.
PMID: 36970371
This paper describes the synthesis of several halogenated S and Se heterocycles and tests their biological activity by measuring the effects on the myeloid leukemia cell line, PLB-985 cells. We...
3.
Yamahashi Y, Cavnar P, Hind L, Berthier E, Bennin D, Beebe D, et al.
Biomed Microdevices
. 2015 Sep;
17(5):100.
PMID: 26354879
Directed neutrophil migration in blood vessels and tissues is critical for proper immune function; however, the mechanisms that regulate three-dimensional neutrophil chemotaxis remain unclear. It has been shown that integrins...
4.
Cavnar P, Mogen K, Berthier E, Beebe D, Huttenlocher A
J Biol Chem
. 2012 Jun;
287(30):25466-77.
PMID: 22679023
HS1 is an actin regulatory protein and cortactin homolog that is expressed in hematopoietic cells. Antigen receptor stimulation induces HS1 phosphorylation, and HS1 is essential for T cell activation. HS1...
5.
Deng Q, Yoo S, Cavnar P, Green J, Huttenlocher A
Dev Cell
. 2011 Oct;
21(4):735-45.
PMID: 22014524
Neutrophil homeostasis is essential for host defense. Here we identify dual roles for Rac2 during neutrophil homeostasis using a zebrafish model of primary immune deficiency induced by the human inhibitory...
6.
Cavnar P, Berthier E, Beebe D, Huttenlocher A
J Cell Biol
. 2011 Apr;
193(3):465-73.
PMID: 21518791
Kostmann disease is an inherited severe congenital neutropenia syndrome associated with loss-of-function mutations in an adaptor protein HS1-associated protein X-1 (Hax1). How Hax1 regulates neutrophil function remains largely unknown. In...
7.
Yoo S, Deng Q, Cavnar P, Wu Y, Hahn K, Huttenlocher A
Dev Cell
. 2010 Feb;
18(2):226-36.
PMID: 20159593
Cell polarity is crucial for directed migration. Here we show that phosphoinositide 3-kinase (PI(3)K) mediates neutrophil migration in vivo by differentially regulating cell protrusion and polarity. The dynamics of PI(3)K...
8.
Cavnar P, Olenych S, Keller 3rd T
Cell Motil Cytoskeleton
. 2007 Mar;
64(6):418-33.
PMID: 17366640
We previously discovered a large titin-like protein-c-titin-in chicken epithelial brush border and human blood platelet extracts that binds alpha-actinin and organizes arrays of myosin II bipolar filaments in vitro. RT-PCR...