Peter Hortschansky
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Explore the profile of Peter Hortschansky including associated specialties, affiliations and a list of published articles.
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73
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2087
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Recent Articles
1.
Torres-Gomez H, Keiff F, Hortschansky P, Bernal F, Kerndl V, Meyer F, et al.
Eur J Med Chem
. 2024 Sep;
279:116849.
PMID: 39265253
Nitrobenzothiazinones (BTZs) are undergoing late-stage development as a novel class of potent antitubercular drug candidates with two compounds in clinical phases. BTZs inhibit decaprenylphosphoryl-β-d-ribose oxidase 1 (DprE1), a key enzyme...
2.
Sachse A, Hasenbein I, Hortschansky P, Schmuck K, Maenz S, Illerhaus B, et al.
J Mater Sci Mater Med
. 2023 Jun;
34(7):31.
PMID: 37378714
Bilateral defects (diameter 8 mm) in the medial tibial head of senile, osteopenic female sheep (n = 48; 9.63 ± 0.10 years; mean ± SEM) were treated with hydroxyapatite (HA)/beta-tricalcium...
3.
Jia L, Rafiq M, Radosa L, Hortschansky P, Cunha C, Cseresnyes Z, et al.
Cell Host Microbe
. 2023 Mar;
31(3):373-388.e10.
PMID: 36893734
The decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human...
4.
Schwarz C, Eschenhagen P, Schmidt H, Hohnstein T, Iwert C, Grehn C, et al.
J Clin Invest
. 2023 Jan;
133(5).
PMID: 36701198
BACKGROUNDThe fungus Aspergillus fumigatus causes a variety of clinical phenotypes in patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi, but the types of A. fumigatus-specific Th...
5.
Kuhbacher A, Peiffer M, Hortschansky P, Merschak P, Bromley M, Haas H, et al.
Microbiol Spectr
. 2022 May;
10(3):e0120922.
PMID: 35575535
Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase...
6.
Huber E, Hortschansky P, Scheven M, Misslinger M, Haas H, Brakhage A, et al.
Structure
. 2022 Apr;
30(7):934-946.e4.
PMID: 35472306
The heterotrimeric CCAAT-binding complex (CBC) is a fundamental eukaryotic transcription factor recognizing the CCAAT box. In certain fungi, like Aspergilli, the CBC cooperates with the basic leucine zipper HapX to...
7.
Hasenbein I, Sachse A, Hortschansky P, Schmuck K, Horbert V, Anders C, et al.
Biomedicines
. 2022 Feb;
10(2).
PMID: 35203721
Effects of hydroxyapatite (HA) particles with bone morphogenetic BMP-2 or GDF-5 were compared in sheep lumbar osteopenia; in vitro release in phosphate-buffered saline (PBS) or sheep serum was assessed by...
8.
Lopez-Berges M, Scheven M, Hortschansky P, Misslinger M, Baldin C, Gsaller F, et al.
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34299357
The airborne fungus causes opportunistic infections in humans with high mortality rates in immunocompromised patients. Previous work established that the bZIP transcription factor HapX is essential for virulence via adaptation...
9.
Page L, Wallstabe J, Lother J, Bauser M, Kniemeyer O, Strobel L, et al.
Front Immunol
. 2021 Jun;
12:659752.
PMID: 34122417
causes life-threatening opportunistic infections in immunocompromised patients. As therapeutic outcomes of invasive aspergillosis (IA) are often unsatisfactory, the development of targeted immunotherapy remains an important goal. Linking the innate and...
10.
Misslinger M, Hortschansky P, Brakhage A, Haas H
Biochim Biophys Acta Mol Cell Res
. 2020 Oct;
1868(1):118885.
PMID: 33045305
To maintain iron homeostasis, fungi have to balance iron acquisition, storage, and utilization to ensure sufficient supply and to avoid toxic excess of this essential trace element. As pathogens usually...