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Kyoung-Han Kim

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Articles 40
Citations 2379
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Recent Articles
1.
Kwon S, Jeyaratnam R, Kim K
J Pharm Pharm Sci . 2024 Oct; 27:13375. PMID: 39403635
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder marked by excessive accumulation of lipids within the liver. If untreated, this condition can progress to metabolic dysfunction-associated steatohepatitis (MASH),...
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Zhang L, Smyth D, Al-Khalaf M, Blet A, Du Q, Bernick J, et al.
Nat Cardiovasc Res . 2024 Aug; 1(12):1195-1214. PMID: 39196168
Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic inflammation. As elderly populations continue to increase, precision treatments for age-related cardiac decline are urgently needed....
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Oh Y, Abid R, Dababneh S, Bakr M, Aslani T, Cook D, et al.
Nat Commun . 2024 Aug; 15(1):6550. PMID: 39095365
The cardiac conduction system (CCS) is a network of specialized cardiomyocytes that coordinates electrical impulse generation and propagation for synchronized heart contractions. Although the components of the CCS, including the...
5.
Ahmed A, Syed J, Chi L, Wang Y, Perez-Romero C, Lee D, et al.
Nat Cardiovasc Res . 2024 Apr; 2(2):174-191. PMID: 38665902
Cardiac metabolism is deranged in heart failure, but underlying mechanisms remain unclear. Here, we show that lysine demethylase 8 (Kdm8) maintains an active mitochondrial gene network by repressing , thus...
6.
Trzaskalski N, Vulesevic B, Nguyen M, Jeraj N, Fadzeyeva E, Morrow N, et al.
JCI Insight . 2022 Dec; 8(2). PMID: 36472923
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4...
7.
Son J, Dou Z, Kim K, Hui C
Int J Obes (Lond) . 2022 Sep; 46(11):2029-2039. PMID: 36115924
Objective: Obesity, a leading cause of several metabolic abnormalities, is mainly caused by imbalanced energy homeostasis. IRX3 and IRX5 have been suggested as genetic determinants of obesity in connection with...
8.
Lu A, Wang J, Xia Y, Gu R, Kim K, Mulvihill E, et al.
J Vis Exp . 2022 Aug; (185). PMID: 35969083
Heart disease is the leading cause of morbidity and mortality worldwide. Due to their low cost, ease of handling, and abundance of transgenic strains, rodents have become essential models for...
9.
Asif S, Kim R, Fatica T, Sim J, Zhao X, Oh Y, et al.
Mol Metab . 2022 Apr; 61:101494. PMID: 35421611
Objective: Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated...
10.
Kim K, Oh Y, Liu J, Dababneh S, Xia Y, Kim R, et al.
Am J Physiol Heart Circ Physiol . 2022 Mar; 322(5):H725-H741. PMID: 35245131
Previous studies have established that transmural gradients of the fast transient outward K current () correlate with regional differences in action potential (AP) profile and excitation-contraction coupling (ECC) with high...