Peter H Backx
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Explore the profile of Peter H Backx including associated specialties, affiliations and a list of published articles.
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163
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7913
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Recent Articles
11.
Li X, Tan W, Zheng S, Pyle W, Zhu C, Chen H, et al.
Front Physiol
. 2022 Mar;
13:777284.
PMID: 35330931
Background: The murine transverse aortic constriction (TAC) model is frequently used to investigate molecular mechanisms underlying heart failure. However, limited data is available regarding the expression of mRNAs and circRNAs...
12.
Kim K, Oh Y, Liu J, Dababneh S, Xia Y, Kim R, et al.
Am J Physiol Heart Circ Physiol
. 2022 Mar;
322(5):H725-H741.
PMID: 35245131
Previous studies have established that transmural gradients of the fast transient outward K current () correlate with regional differences in action potential (AP) profile and excitation-contraction coupling (ECC) with high...
13.
Li X, Tan W, Zheng S, Zhang J, Zhu C, Cai C, et al.
Front Cardiovasc Med
. 2022 Jan;
8:788270.
PMID: 35047577
Pressure overload can result in dilated cardiomyopathy. The beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on heart disorders have been widely recognized. However, the molecular mechanisms underlying their...
14.
Barazi N, Polidovitch N, Debi R, Yakobov S, Lakin R, Backx P
Front Physiol
. 2021 Nov;
12:692247.
PMID: 34733171
Heart rate (HR) and blood pressure as well as adverse cardiovascular events show clear circadian patterns, which are linked to interdependent daily variations in physical activity and cardiac autonomic nerve...
15.
Tan W, Li X, Zheng S, Li X, Zhang X, Pyle W, et al.
Front Cardiovasc Med
. 2021 Jun;
8:677727.
PMID: 34150870
Heart failure is induced by multiple pathological mechanisms, and current therapies are ineffective against heart failure with preserved ejection fraction (HFpEF). As there are limited animal models of HFpEF, its...
16.
17.
Zheng S, Tan W, Li X, Li B, Gong B, Pyle W, et al.
J Cardiovasc Transl Res
. 2021 Feb;
14(5):799-815.
PMID: 33591467
Aged nonhuman primate (NHP) models are of great value for studying the pathology of metabolic heart diseases and developing therapeutic strategies. In this study, aged male cynomolgus monkeys were fed...
18.
Oh Y, Yang S, Liu X, Jana S, Izaddoustdar F, Gao X, et al.
Front Physiol
. 2021 Jan;
11:605671.
PMID: 33424629
Atrial Fibrillation (AF) is the most common supraventricular tachyarrhythmia that is typically associated with cardiovascular disease (CVD) and poor cardiovascular health. Paradoxically, endurance athletes are also at risk for AF....
19.
Lakin R, Debi R, Yang S, Polidovitch N, Goodman J, Backx P
Am J Physiol Heart Circ Physiol
. 2021 Jan;
320(4):H1261-H1275.
PMID: 33416456
Acute exhaustive endurance exercise can differentially impact the right ventricle (RV) versus the left ventricle (LV). However, the hemodynamic basis for these differences and its impact on postexercise recovery remain...
20.
Kim Y, Lakin R, Zhang H, Liu J, Sachedina A, Singh M, et al.
JCI Insight
. 2020 Sep;
5(17).
PMID: 32879139
Previous studies have shown an association between elevated atrial NADPH-dependent oxidative stress and decreased plasma apelin in patients with atrial fibrillation (AF), though the basis for this relationship is unclear....