Peter E Maligres
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Explore the profile of Peter E Maligres including associated specialties, affiliations and a list of published articles.
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15
Citations
182
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Recent Articles
1.
Benkovics T, Peng F, Phillips E, An C, Bade R, Chung C, et al.
J Am Chem Soc
. 2022 Mar;
144(13):5855-5863.
PMID: 35333525
As practitioners of organic chemistry strive to deliver efficient syntheses of the most complex natural products and drug candidates, further innovations in synthetic strategies are required to facilitate their efficient...
2.
McIntosh J, Benkovics T, Silverman S, Huffman M, Kong J, Maligres P, et al.
ACS Cent Sci
. 2021 Dec;
7(12):1980-1985.
PMID: 34963891
Molnupiravir (MK-4482) is an investigational antiviral agent that is under development for the treatment of COVID-19. Given the potential high demand and urgency for this compound, it was critical to...
3.
Klapars A, Chung J, Limanto J, Calabria R, Campeau L, Campos K, et al.
Chem Sci
. 2021 Jul;
12(26):9031-9036.
PMID: 34276931
An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of...
4.
Mao E, Chung C, Ji Y, Lam Y, Maligres P
J Org Chem
. 2021 May;
86(11):7529-7536.
PMID: 34033478
A class of organocatalysts that are highly active for the conversion of 2'-deoxynucleosides to furanoid glycals have been discovered. These phosphorimides, (PhPS)NH and (PhPSe)NH, were shown to effectively mediate persilylation...
5.
Shen F, Tyagarajan S, Perera D, Krska S, Maligres P, Smith 3rd M, et al.
Org Lett
. 2016 Mar;
18(7):1554-7.
PMID: 26998615
Bismuth(III) acetate is a safe, inexpensive, and selective facilitator of sequential protodeboronations, which when used in conjunction with Ir-catalyzed borylations allows access to a diversity of borylated indoles. The versatility...
6.
Chung C, Cleator E, Dumas A, Hicks J, Humphrey G, Maligres P, et al.
Org Lett
. 2016 Mar;
18(6):1394-7.
PMID: 26950496
The development of a convergent and highly stereoselective synthesis of an HCV NS3/4a protease inhibitor possessing a unique spirocyclic and macrocyclic architecture is described. A late-stage spirocyclization strategy both enabled...
7.
Christensen M, Nolting A, Shevlin M, Weisel M, Maligres P, Lee J, et al.
J Org Chem
. 2016 Jan;
81(3):824-30.
PMID: 26743694
α- and β-substitution of dihydrocinnamates has been shown to increase the biological activity of various drug candidates. Recently, we identified enantio- and diastereopure α-methyl-β-cyclopropyldihydrocinnamates to be important pharmacophores in one...
8.
Li H, Chen C, Nguyen H, Cohen R, Maligres P, Yasuda N, et al.
J Org Chem
. 2014 Aug;
79(18):8533-40.
PMID: 25162915
A general and efficient asymmetric synthesis of cyclic indoline aminals was developed with a high level of 1,3-stereoinduction through a dynamic crystallization-driven condensation. Dehydrogenation of the indoline aminals with potassium...
9.
Ghaffari B, Preshlock S, Plattner D, Staples R, Maligres P, Krska S, et al.
J Am Chem Soc
. 2014 Aug;
136(41):14345-8.
PMID: 25141136
Ir catalysts supported by bidentate silyl ligands that contain P- or N-donors are shown to effect ortho borylations for a range of substituted aromatics. The substrate scope is broad, and...
10.
Preshlock S, Plattner D, Maligres P, Krska S, Maleczka Jr R, Smith 3rd M
Angew Chem Int Ed Engl
. 2013 Nov;
52(49):12915-9.
PMID: 24222178
Not a trace: Borylation of the nitrogen in nitrogen heterocycles or anilines provides a traceless directing group for subsequent catalytic C-H borylation. Selectivities that previously required Boc protection can be...