Michael Shevlin
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Explore the profile of Michael Shevlin including associated specialties, affiliations and a list of published articles.
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28
Citations
567
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Recent Articles
1.
de Souza D, Pablo Z, Shevlin M, von Furstenberg M, Banks J, Sarker D, et al.
J Intellect Dev Disabil
. 2025 Jan;
49(1):95-106.
PMID: 39815935
Background: Research on post-secondary training for individuals with intellectual disabilities has generally focused on programs, with little consideration of the structures and mechanisms that give rise to them. This article...
2.
Selingo J, Greenwood J, Andrews M, Patel C, Neel A, Pio B, et al.
J Am Chem Soc
. 2023 Dec;
146(1):936-945.
PMID: 38153812
Methods to synthesize diverse collections of substituted piperidines are valuable due to the prevalence of this heterocycle in pharmaceutical compounds. Here, we present a general strategy to access -(hetero)arylpiperidines using...
3.
Alonso L, Shevlin M, Alshreimi A, Reidl T, Wink D, Anderson L
Chemistry
. 2023 Feb;
29(30):e202300551.
PMID: 36840693
The roles of substituent and solvent effects in promoting the 4π electrocyclization of N-alkenylnitrones to give azetidine nitrones have been investigated by experimental examination of relative rates, activation energies, and...
4.
Felten S, He C, Weisel M, Shevlin M, Emmert M
J Am Chem Soc
. 2022 Dec;
144(50):23115-23126.
PMID: 36490321
This manuscript describes a mild, functional group tolerant, and metal-free C-H carboxylation that enables direct access to azole-2-carboxylic acids, followed by amide coupling in one pot. This demonstrates a significant...
5.
Mendelsohn L, Pavlovic L, Zhong H, Friedfeld M, Shevlin M, Hopmann K, et al.
J Am Chem Soc
. 2022 Aug;
144(34):15764-15778.
PMID: 35951601
The mechanism of the asymmetric hydrogenation of prochiral enamides by well-defined, neutral bis(phosphine) cobalt(0) and cobalt(II) precatalysts has been explored using(,)-DuPhos ((,)-DuPhos = (+)-1,2-bis[(2,5)-2,5-diisopropylphospholano]benzene) as a representative chiral bis(phosphine) ligand....
6.
Nesic M, Ryffel D, Maturano J, Shevlin M, Pollack S, Gauthier Jr D, et al.
J Am Chem Soc
. 2022 Jul;
144(31):14026-14030.
PMID: 35900216
The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a convergent fashion with a longest linear sequence of 16...
7.
Zhong Y, Moore J, Shevlin M, Shultz C, Kosjek B, Chen Y, et al.
J Org Chem
. 2021 Sep;
87(4):2120-2128.
PMID: 34582192
Two scalable and efficient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed from a simple pyridine building block. The key step to set the...
8.
Klapars A, Chung J, Limanto J, Calabria R, Campeau L, Campos K, et al.
Chem Sci
. 2021 Jul;
12(26):9031-9036.
PMID: 34276931
An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of...
9.
Schuster C, Dropinski J, Shevlin M, Li H, Chen S
Org Lett
. 2020 Sep;
22(19):7562-7566.
PMID: 32946691
Prochiral hydrazones undergo efficient and highly selective hydrogenation in the presence of a chiral diphosphine ruthenium catalyst, yielding enantioenriched hydrazine products (up to 99% ). The mild reaction conditions and...
10.
Zhong H, Shevlin M, Chirik P
J Am Chem Soc
. 2020 Feb;
142(11):5272-5281.
PMID: 32064867
The asymmetric hydrogenation of α,β-unsaturated carboxylic acids using readily prepared bis(phosphine) cobalt(0) 1,5-cyclooctadiene precatalysts is described. Di-, tri-, and tetra-substituted acrylic acid derivatives with various substitution patterns as well as...