Peter E Kima
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Explore the profile of Peter E Kima including associated specialties, affiliations and a list of published articles.
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31
Citations
559
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Recent Articles
11.
Zhang N, Prasad S, Huyghues Despointes C, Young J, Kima P
Cell Microbiol
. 2018 Jul;
20(11):e12889.
PMID: 29993167
Miltefosine is an important drug for the treatment of leishmaniasis; however, its mechanism of action is still poorly understood. In these studies, we tested the hypothesis that like in cancer...
12.
Craig E, Huyghues-Despointes C, Yu C, Handy E, Sello J, Kima P
PLoS Negl Trop Dis
. 2017 May;
11(5):e0005556.
PMID: 28505157
In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway...
13.
Kima P
Cell Immunol
. 2016 Sep;
309:19-22.
PMID: 27622385
PI3K signaling plays a role in the host response to Leishmania infections. At the cellular level PI3K signaling is engaged by the parasite to control several cellular processes, which ensures...
14.
Zhang N, Kima P
Front Immunol
. 2016 May;
7:146.
PMID: 27148265
Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is an increasing appreciation that dysregulated expression of protein kinases promotes the success...
15.
Kima P
Microbes Infect
. 2014 Aug;
16(9):721-6.
PMID: 25107580
Parasites of the Leishmania genus are the causative agents of a complex disease called leishmaniasis. Many activities of infected cells including their responses to a range of stimuli are modulated...
16.
Henard C, Carlsen E, Hay C, Kima P, Soong L
PLoS Negl Trop Dis
. 2014 Jul;
8(7):e3000.
PMID: 25033301
Professional phagocytes generate a myriad of antimicrobial molecules to kill invading microorganisms, of which nitrogen oxides are integral in controlling the obligate intracellular pathogen Leishmania. Although reactive nitrogen species produced...
17.
Kima P, Soong L
Front Immunol
. 2013 Jun;
4:156.
PMID: 23801993
Leishmaniasis is a complex disease that is caused by parasites of the Leishmania genus. Leishmania are further classified into several complexes, each of which can engage in distinct interactions with...
18.
Canton J, Kima P
Am J Pathol
. 2012 Aug;
181(4):1348-55.
PMID: 22885104
Our previous observations established a role for syntaxin-5 in the development of Leishmania parasitophorous vacuoles (LPVs). In this study, we took advantage of the recent identification of Retro-2, a small...
19.
Canton J, Kima P
Cell Microbiol
. 2012 Aug;
14(11):1676-86.
PMID: 22862745
A subgroup of intracellular pathogens reside and replicate within membrane-bound compartments often termed pathogen-containing compartments (PCC). PCCs navigate around a wide range of host cell vesicles and organelles. In light...
20.
Canton J, Ndjamen B, Hatsuzawa K, Kima P
Cell Microbiol
. 2012 Feb;
14(6):937-48.
PMID: 22309219
Parasitophorous vacuoles (PV) that harbour Leishmania parasites acquire some characteristics from fusion with host cell vesicles. Recent studies have shown that PVs acquire and display resident endoplasmic reticulum (ER) molecules....