Interferon Gamma in Leishmaniasis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Jun 27

PMID 23801993

Citations 47

Authors

Peter E Kima

Lynn Soong

Affiliations

Soon will be listed here.

Abstract

Leishmaniasis is a complex disease that is caused by parasites of the Leishmania genus. Leishmania are further classified into several complexes, each of which can engage in distinct interactions with mammalian hosts resulting in differing disease presentations. It is therefore not unexpected that host immune responses to Leishmania are variable. The induction of interferon gamma (IFN-γ) and response to it in these infections has received considerable attention. In this review, we summarize our current understanding of some of the host responses during Leishmania infections that are regulated by IFN-γ. In addition, studies that explore the nature of parasite-derived molecular mediators that might affect the host response to IFN-γ are also discussed.

Citing Articles

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References

Alexander J, Brombacher F . T helper1/t helper2 cells and resistance/susceptibility to leishmania infection: is this paradigm still relevant?. Front Immunol. 2012; 3:80. PMC: 3342373. DOI: 10.3389/fimmu.2012.00080. View

Muller A, Filipe-Santos O, Eberl G, Aebischer T, Spath G, Bousso P . CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity. 2012; 37(1):147-57. DOI: 10.1016/j.immuni.2012.05.015. View

Liu M, Guo S, Hibbert J, Jain V, Singh N, Wilson N . CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 2011; 22(3):121-30. PMC: 3203691. DOI: 10.1016/j.cytogfr.2011.06.001. View

Mosmann T, Cherwinski H, Bond M, Giedlin M, Coffman R . Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986; 136(7):2348-57. View

Qi H, Ji J, Wanasen N, Soong L . Enhanced replication of Leishmania amazonensis amastigotes in gamma interferon-stimulated murine macrophages: implications for the pathogenesis of cutaneous leishmaniasis. Infect Immun. 2004; 72(2):988-95. PMC: 321581. DOI: 10.1128/IAI.72.2.988-995.2004. View

Johnson H, Noon-Song E, Kemppainen K, Ahmed C . Steroid-like signalling by interferons: making sense of specific gene activation by cytokines. Biochem J. 2012; 443(2):329-38. PMC: 3509199. DOI: 10.1042/BJ20112187. View

Schnorr D, Muniz A, Passos S, Guimaraes L, Lago E, Bacellar O . IFN-γ production to leishmania antigen supplements the leishmania skin test in identifying exposure to L. braziliensis infection. PLoS Negl Trop Dis. 2013; 6(12):e1947. PMC: 3527349. DOI: 10.1371/journal.pntd.0001947. View

Gonzalez-Lombana C, Santiago H, Macedo J, Seixas V, Russo R, Tafuri W . Early infection with Leishmania major restrains pathogenic response to Leishmania amazonensis and parasite growth. Acta Trop. 2008; 106(1):27-38. DOI: 10.1016/j.actatropica.2007.12.012. View

Liu M, Guo S, Stiles J . The emerging role of CXCL10 in cancer (Review). Oncol Lett. 2012; 2(4):583-589. PMC: 3406435. DOI: 10.3892/ol.2011.300. View

10.

Soong L, Henard C, Melby P . Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis. Semin Immunopathol. 2012; 34(6):735-51. PMC: 4111229. DOI: 10.1007/s00281-012-0350-8. View

11.

Kaiko G, Horvat J, Beagley K, Hansbro P . Immunological decision-making: how does the immune system decide to mount a helper T-cell response?. Immunology. 2007; 123(3):326-38. PMC: 2433332. DOI: 10.1111/j.1365-2567.2007.02719.x. View

12.

Xin L, Wanderley J, Wang Y, Vargas-Inchaustegui D, Soong L . The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice. Parasite Immunol. 2011; 33(3):170-80. PMC: 4118816. DOI: 10.1111/j.1365-3024.2010.01268.x. View

13.

Vargas-Inchaustegui D, Tai W, Xin L, Hogg A, Corry D, Soong L . Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice. Infect Immun. 2009; 77(7):2948-56. PMC: 2708571. DOI: 10.1128/IAI.00154-09. View

14.

Ji J, Sun J, Soong L . Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis. Infect Immun. 2003; 71(8):4278-88. PMC: 166010. DOI: 10.1128/IAI.71.8.4278-4288.2003. View

15.

Mottram J, Coombs G, Alexander J . Cysteine peptidases as virulence factors of Leishmania. Curr Opin Microbiol. 2004; 7(4):375-81. DOI: 10.1016/j.mib.2004.06.010. View

16.

Muller M, Carter S, Hofer M, Campbell I . Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrum. Neuropathol Appl Neurobiol. 2010; 36(5):368-87. DOI: 10.1111/j.1365-2990.2010.01089.x. View

17.

Vargas-Inchaustegui D, Xin L, Soong L . Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. J Immunol. 2008; 180(11):7537-45. PMC: 2641013. DOI: 10.4049/jimmunol.180.11.7537. View

18.

Majumder S, Bhattacharjee S, Chowdhury B, Majumdar S . CXCL10 is critical for the generation of protective CD8 T cell response induced by antigen pulsed CpG-ODN activated dendritic cells. PLoS One. 2012; 7(11):e48727. PMC: 3492407. DOI: 10.1371/journal.pone.0048727. View

19.

Rautajoki K, Kylaniemi M, Raghav S, Rao K, Lahesmaa R . An insight into molecular mechanisms of human T helper cell differentiation. Ann Med. 2008; 40(5):322-35. DOI: 10.1080/07853890802068582. View

20.

de Souza M, de Assis E, Gomes R, Marques Da Silva E, Melo M, Fietto J . The influence of ecto-nucleotidases on Leishmania amazonensis infection and immune response in C57B/6 mice. Acta Trop. 2010; 115(3):262-9. DOI: 10.1016/j.actatropica.2010.04.007. View