Peter Backx
Overview
Explore the profile of Peter Backx including associated specialties, affiliations and a list of published articles.
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11
Citations
144
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Recent Articles
1.
Siraj M, Mundil D, Beca S, Momen A, Shikatani E, Afroze T, et al.
J Clin Invest
. 2020 Jan;
130(3):1392-1404.
PMID: 31985487
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36),...
2.
Jackson N, Masse S, Zamiri N, Azam M, Lai P, Kusha M, et al.
JACC Clin Electrophysiol
. 2018 May;
1(3):187-197.
PMID: 29759364
Objectives: This study sought to determine the characteristics of human LDVF, particularly as it contrasts with short-duration VF (SDVF), and evaluate the role of Purkinje fibers in its maintenance. Background:...
3.
Barichello S, Roberts J, Backx P, Boyle P, Laksman Z
Cardiovasc Res
. 2018 Apr;
114(7):931-943.
PMID: 29648634
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with substantial morbidity. There is considerable inter-patient variability in the pathologic processes that promote AF, and this variability...
4.
Sadi A, Afroze T, Siraj M, Momen A, White-Dzuro C, Zarrin-Khat D, et al.
Clin Sci (Lond)
. 2018 Mar;
132(6):641-654.
PMID: 29487197
Heart failure (HF) is associated with reduced expression of plasma membrane Ca-ATPase 4 (PMCA4). Cardiac-specific overexpression of human PMCA4b in mice inhibited nNOS activity and reduced cardiac hypertrophy by inhibiting...
5.
Xie L, Liang T, Kang Y, Lin X, Sobbi R, Xie H, et al.
J Mol Cell Cardiol
. 2014 Jul;
75:100-10.
PMID: 25073062
Cardiac sarcolemmal syntaxin (Syn)-1A interacts with sulfonylurea receptor (SUR) 2A to inhibit ATP-sensitive potassium (KATP) channels. Phosphatidylinositol 4,5-bisphosphate (PIP2), a ubiquitous endogenous inositol phospholipid, known to bind Kir6.2 subunit to...
6.
Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, et al.
PLoS One
. 2014 Jan;
9(1):e82179.
PMID: 24427266
Rationale: Structural differences between ventricular regions may not be the sole determinant of local ventricular fibrillation (VF) dynamics and molecular remodeling may play a role. Objectives: To define regional ion...
7.
Zamiri N, Masse S, Ramadeen A, Kusha M, Hu X, Azam M, et al.
Circulation
. 2014 Jan;
129(8):875-85.
PMID: 24403563
Background: Resistant ventricular fibrillation, refibrillation. and diminished myocardial contractility are important factors leading to poor survival after cardiac arrest. We hypothesized that dantrolene improves survival after ventricular fibrillation (VF) by...
8.
Kelsey L, Flenniken A, Qu D, Funnell A, Pearson R, Zhou Y, et al.
PLoS Genet
. 2013 Jul;
9(7):e1003612.
PMID: 23874215
KLF3 is a Krüppel family zinc finger transcription factor with widespread tissue expression and no previously known role in heart development. In a screen for dominant mutations affecting cardiovascular function...
9.
Papp S, Dziak E, Kabir G, Backx P, Clement S, Opas M
Am J Pathol
. 2010 Jan;
176(3):1113-21.
PMID: 20110410
While calreticulin has been shown to be critical for cardiac development, its role in cardiac pathology is unclear. Previous studies have shown the detrimental effects on the heart of sustained...
10.
Ricci R, Eriksson U, Oudit G, Eferl R, Akhmedov A, Sumara I, et al.
Genes Dev
. 2005 Jan;
19(2):208-13.
PMID: 15655111
Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical pressure overload,...