Perry C Kennedy
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Explore the profile of Perry C Kennedy including associated specialties, affiliations and a list of published articles.
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7
Citations
144
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Recent Articles
1.
East J, Carter K, Kennedy P, Schulte N, Toews M, Lynch K, et al.
Medchemcomm
. 2011 Dec;
2(4):325-330.
PMID: 22180836
Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention due to its role in neoplastic diseases. Our group has developed a potent dual LPA1/LPA3 receptor antagonist, VPC51098 (LPA1...
2.
Callihan P, Zitomer N, Stoeling M, Kennedy P, Lynch K, Riley R, et al.
Neuropharmacology
. 2011 Oct;
62(2):988-96.
PMID: 22016110
In vivo and in vitro studies suggest a crucial role for Sphingosine 1-phosphate (S1P) and its receptors in the development of the nervous system. Dihydrosphingosine 1-phosphate (dhS1P), a reduced form...
3.
Kharel Y, Mathews T, Gellett A, Tomsig J, Kennedy P, Moyer M, et al.
Biochem J
. 2011 Aug;
440(3):345-53.
PMID: 21848514
S1P (sphingosine 1-phosphate) is a signalling molecule involved in a host of cellular and physiological functions, most notably cell survival and migration. S1P, which signals via a set of five...
4.
Kennedy P, Zhu R, Huang T, Tomsig J, Mathews T, David M, et al.
J Pharmacol Exp Ther
. 2011 Jun;
338(3):879-89.
PMID: 21632869
Sphingosine 1-phosphate (S1P) is a phospholipid that binds to a set of G protein-coupled receptors (S1P(1)-S1P(5)) to initiate an array of signaling cascades that affect cell survival, differentiation, proliferation, and...
5.
Mathews T, Kennedy A, Kharel Y, Kennedy P, Nicoara O, Sunkara M, et al.
J Med Chem
. 2010 Mar;
53(7):2766-78.
PMID: 20205392
Sphingosine 1-phosphate (S1P), a potent phospholipid growth and trophic factor, is synthesized in vivo by two sphingosine kinases. Thus these kinases have been proposed as important drug targets for treatment...
6.
Foss Jr F, Mathews T, Kharel Y, Kennedy P, Snyder A, Davis M, et al.
Bioorg Med Chem
. 2009 Jul;
17(16):6123-36.
PMID: 19632123
In the search for bioactive sphingosine 1-phosphate (S1P) receptor ligands, a series of 2-amino-2-heterocyclic-propanols were synthesized. These molecules were discovered to be substrates of human-sphingosine kinases 1 and 2 (SPHK1...
7.
Zhu R, Snyder A, Kharel Y, Schaffter L, Sun Q, Kennedy P, et al.
J Med Chem
. 2007 Nov;
50(25):6428-35.
PMID: 17994678
Compound 1 (FTY720, Fingolimod) represents a new generation of immunosuppressant that modulates lymphocyte trafficking by interacting with the S1P(1) receptor. Compound 1 also provides a template molecule for studying the...