Pengxu Qian
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Explore the profile of Pengxu Qian including associated specialties, affiliations and a list of published articles.
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96
Citations
2136
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Recent Articles
1.
Wang H, Zhang Z, Han C, Jiang P, Xu J, Han Y, et al.
Nat Cell Biol
. 2025 Jan;
27(2):246-261.
PMID: 39890952
Haematopoietic stem cells (HSCs) self-renew and differentiate to replenish the pool of blood cells, which require a low but finely tuned protein synthesis rate. Nonetheless, the translatome landscape in HSCs...
2.
Chen J, Li Y, Wang Y, Wang H, Yang J, Pan X, et al.
EMBO J
. 2024 Nov;
43(24):6591-6625.
PMID: 39567829
Tissue homeostasis and regeneration involve complex cellular changes. The role of rRNA modification-dependent translational regulation in these processes remains largely unknown. Planarians, renowned for their ability to undergo remarkable tissue...
3.
Wang X, Tao X, Chen P, Jiang P, Li W, Chang H, et al.
Signal Transduct Target Ther
. 2024 Oct;
9(1):293.
PMID: 39438476
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used...
4.
Liu L, Shao M, Huang Y, Qian P, Huang H
J Hematol Oncol
. 2024 Oct;
17(1):95.
PMID: 39396039
Due to spatial and genomic independence, mitochondria possess a translational mechanism distinct from that of cytoplasmic translation. Several regulators participate in the modulation of mitochondrial translation. Mitochondrial translation is coordinated...
5.
Jin C, Jiang P, Zhang Z, Han Y, Wen X, Zheng L, et al.
Nat Commun
. 2024 Oct;
15(1):8690.
PMID: 39375367
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by multilineage immune dysregulation, which subsequently causes inflammation, fibrosis, and even cirrhosis of liver. Due to the limitation of...
6.
Yu Z, Li J, Wen X, Han Y, Jiang P, Zhu M, et al.
J Hematol Oncol
. 2024 Aug;
17(1):59.
PMID: 39090716
No abstract available.
7.
Huang D, Yu Z, Lu H, Jiang P, Qian X, Han Y, et al.
Cancer Res
. 2024 Jul;
84(13):2090-2108.
PMID: 39082681
Acute myeloid leukemia (AML) is an aggressive and heterogeneous hematologic malignancy. In elderly patients, AML incidence is high and has a poor prognosis due to a lack of effective therapies....
8.
Li Y, Zhang B, Jiang L, Cheng T, Cheng H, Qian P
Blood Sci
. 2024 Jul;
6(4):e00200.
PMID: 39027904
Accumulated evidence emerges that dynamic changes in human gut microbiota and microbial metabolites can alter the ecological balance of symbiotic hosts. The gut microbiota plays a role in various diseases...
9.
Zeng X, Shi C, Han Y, Hu K, Li X, Wei C, et al.
Nat Aging
. 2024 Jul;
4(10):1477-1492.
PMID: 39020094
Aging of hematopoietic stem cells (HSCs) is accompanied by impaired self-renewal ability, myeloid skewing, immunodeficiencies and increased susceptibility to malignancies. Although previous studies highlighted the pivotal roles of individual metabolites...
10.
Li J, Wu H, Yu Z, Wang Q, Zeng X, Qian W, et al.
Nat Commun
. 2024 Jul;
15(1):5689.
PMID: 38971796
Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs to the...