Pelin Uluocak
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Explore the profile of Pelin Uluocak including associated specialties, affiliations and a list of published articles.
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8
Citations
612
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Recent Articles
1.
Karuppiah V, Sangani D, Whaley L, Pengelly R, Uluocak P, Carreira R, et al.
Sci Rep
. 2024 Nov;
14(1):26851.
PMID: 39500929
Specificity of a T cell receptor (TCR) is determined by the combination of its interactions to the peptide and human leukocyte antigen (HLA). TCR-based therapeutic molecules have to date targeted...
2.
Geraghty Z, Barnard C, Uluocak P, Gruneberg U
J Cell Sci
. 2020 Dec;
134(1).
PMID: 33288550
Errors in mitotic chromosome segregation can lead to DNA damage and aneuploidy, both hallmarks of cancer. To achieve synchronous error-free segregation, mitotic chromosomes must align at the metaphase plate with...
3.
Gligoris T, Scheinost J, Burmann F, Petela N, Chan K, Uluocak P, et al.
Science
. 2014 Nov;
346(6212):963-7.
PMID: 25414305
Through their association with a kleisin subunit (Scc1), cohesin's Smc1 and Smc3 subunits are thought to form tripartite rings that mediate sister chromatid cohesion. Unlike the structure of Smc1/Smc3 and...
4.
Espert A, Uluocak P, Bastos R, Mangat D, Graab P, Gruneberg U
J Cell Biol
. 2014 Sep;
206(7):833-42.
PMID: 25246613
The spindle assembly checkpoint (SAC) monitors correct attachment of chromosomes to microtubules, an important safeguard mechanism ensuring faithful chromosome segregation in eukaryotic cells. How the SAC signal is turned off...
5.
Farcas A, Uluocak P, Helmhart W, Nasmyth K
Mol Cell
. 2011 Oct;
44(1):97-107.
PMID: 21981921
The contribution of DNA catenation to sister chromatid cohesion is unclear partly because it has never been observed directly within mitotic chromosomes. Differential sedimentation-velocity and gel electrophoresis reveal that sisters...
6.
Beckouet F, Hu B, B Roig M, Sutani T, Komata M, Uluocak P, et al.
Mol Cell
. 2010 Sep;
39(5):689-99.
PMID: 20832721
Sister chromatid cohesion is thought to involve entrapment of sister DNAs by a tripartite ring composed of the cohesin subunits Smc1, Smc3, and Scc1. Establishment of cohesion during S phase...
7.
Rowland B, B Roig M, Nishino T, Kurze A, Uluocak P, Mishra A, et al.
Mol Cell
. 2009 Mar;
33(6):763-74.
PMID: 19328069
Cohesin's Smc1, Smc3, and Scc1 subunits form a tripartite ring that entraps sister DNAs. Scc3, Pds5, and Rad61 (Wapl) are regulatory subunits that control this process. We describe here smc3,...
8.
Gregan J, Zhang C, Rumpf C, Cipak L, Li Z, Uluocak P, et al.
Nat Protoc
. 2007 Nov;
2(11):2996-3000.
PMID: 18007635
Reversible protein phosphorylation is a major regulatory mechanism in a cell. A chemical-genetic strategy to conditionally inactivate protein kinases has been developed recently. Mutating a single residue in the ATP-binding...