Pedro J Gonzalez-Cabrera
Overview
Explore the profile of Pedro J Gonzalez-Cabrera including associated specialties, affiliations and a list of published articles.
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20
Citations
972
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Recent Articles
1.
Sanna M, Vincent K, Repetto E, Nguyen N, Brown S, Abgaryan L, et al.
Mol Pharmacol
. 2015 Oct;
89(1):176-86.
PMID: 26494861
The molecular pharmacology of the G protein-coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P3 antagonist, SPM-354, with in...
2.
Gonzalez-Cabrera P, Brown S, Studer S, Rosen H
F1000Prime Rep
. 2015 Jan;
6:109.
PMID: 25580263
Development of sphingosine-1-phosphate receptor 1 (S1P1) modulators to dampen inflammation and its sequelae is becoming increasingly promising for treating medical conditions characterized by significant immunopathology. As shown by the non-selective...
3.
Rosen H, Sanna M, Gonzalez-Cabrera P, Roberts E
Curr Top Microbiol Immunol
. 2014 Apr;
378:1-21.
PMID: 24728591
The understanding of the role of the sphingosine 1-phosphate signaling system in immunology and host defense has deepened exponentially over the past 12 years since the discovery that lymphocyte egress...
4.
Cahalan S, Gonzalez-Cabrera P, Nguyen N, Guerrero M, Cisar E, Leaf N, et al.
Mol Pharmacol
. 2012 Dec;
83(2):316-21.
PMID: 23204443
Sphingosine 1-phosphate receptor 1 (S1P(1)) is a G protein-coupled receptor that is critical for proper lymphocyte development and recirculation. Agonists to S1P(1) are currently in use clinically for the treatment...
5.
Sarkisyan G, Cahalan S, Gonzalez-Cabrera P, Leaf N, Rosen H
Am J Physiol Cell Physiol
. 2012 Feb;
302(10):C1460-8.
PMID: 22357735
Lymph nodes are highly organized structures specialized for efficient regulation of adaptive immunity. The blood and lymphatic systems within a lymph node play essential roles by providing functionally distinct environments...
6.
Gonzalez-Cabrera P, Cahalan S, Nguyen N, Sarkisyan G, Leaf N, Cameron M, et al.
Mol Pharmacol
. 2011 Oct;
81(2):166-74.
PMID: 22031473
Multiple sclerosis (MS) therapies modulate T-cell autoimmunity in the central nervous system (CNS) but may exacerbate latent infections. Fingolimod, a nonselective sphingosine-1-phosphate (S1P) receptor agonist that induces sustained lymphopenia and...
7.
Cahalan S, Gonzalez-Cabrera P, Sarkisyan G, Nguyen N, Schaeffer M, Huang L, et al.
Nat Chem Biol
. 2011 Mar;
7(5):254-6.
PMID: 21445057
Sphingosine 1-phosphate receptor 1 (S1P(1)) is critical for lymphocyte recirculation and is a clinical target for treatment of multiple sclerosis. By generating a short-duration S1P(1) agonist and mice in which...
8.
Rosen H, Gonzalez-Cabrera P, Sanna M, Brown S
Annu Rev Biochem
. 2009 Feb;
78:743-68.
PMID: 19231986
The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties interacts with five high-affinity G protein-coupled receptors to generate...
9.
Gonzalez-Cabrera P, Jo E, Sanna M, Brown S, Leaf N, Marsolais D, et al.
Mol Pharmacol
. 2008 Aug;
74(5):1308-18.
PMID: 18708635
Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane...
10.
Schurer S, Brown S, Gonzalez-Cabrera P, Schaeffer M, Chapman J, Jo E, et al.
ACS Chem Biol
. 2008 Jul;
3(8):486-98.
PMID: 18590333
We have studied the sphingosine 1-phosphate (S1P) receptor system to better understand why certain molecular targets within a closely related family are much more tractable when identifying compelling chemical leads....