Stuart M Cahalan
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Explore the profile of Stuart M Cahalan including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1980
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0
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Recent Articles
1.
Jairaman A, Othy S, Dynes J, Yeromin A, Zavala A, Greenberg M, et al.
Sci Adv
. 2021 Jul;
7(28).
PMID: 34233878
T lymphocytes encounter complex mechanical cues during an immune response. The mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial infections, wound healing, and cancer; however, its role in helper...
2.
Murthy S, Dubin A, Whitwam T, Jojoa-Cruz S, Cahalan S, Mousavi S, et al.
Elife
. 2018 Nov;
7.
PMID: 30382938
Mechanically activated (MA) ion channels convert physical forces into electrical signals, and are essential for eukaryotic physiology. Despite their importance, few bona-fide MA channels have been described in plants and...
3.
Kefauver J, Saotome K, Dubin A, Pallesen J, Cottrell C, Cahalan S, et al.
Elife
. 2018 Aug;
7.
PMID: 30095067
SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other...
4.
Xu J, Mathur J, Vessieres E, Hammack S, Nonomura K, Favre J, et al.
Cell
. 2018 Apr;
173(3):762-775.e16.
PMID: 29677517
Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark...
5.
Dubin A, Murthy S, Lewis A, Brosse L, Cahalan S, Grandl J, et al.
Neuron
. 2017 Apr;
94(2):266-270.e3.
PMID: 28426961
A gold standard for characterizing mechanically activated (MA) currents is via heterologous expression of candidate channels in naive cells. Two recent studies described MA channels using this paradigm. TMEM150c was...
6.
Dubin A, Murthy S, Lewis A, Brosse L, Cahalan S, Grandl J, et al.
Neuron
. 2017 Apr;
94(2):265.
PMID: 28426960
No abstract available.
7.
Syeda R, Qiu Z, Dubin A, Murthy S, Florendo M, Mason D, et al.
Cell
. 2016 Jan;
164(3):499-511.
PMID: 26824658
The volume-regulated anion channel (VRAC) is activated when a cell swells, and it plays a central role in maintaining cell volume in response to osmotic challenges. SWELL1 (LRRC8A) was recently...
8.
Sanna M, Vincent K, Repetto E, Nguyen N, Brown S, Abgaryan L, et al.
Mol Pharmacol
. 2015 Oct;
89(1):176-86.
PMID: 26494861
The molecular pharmacology of the G protein-coupled receptors for sphingosine 1-phosphate (S1P) provides important insight into established and new therapeutic targets. A new, potent bitopic S1P3 antagonist, SPM-354, with in...
9.
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
Lukacs V, Mathur J, Mao R, Bayrak-Toydemir P, Procter M, Cahalan S, et al.
Nat Commun
. 2015 Sep;
6:8329.
PMID: 26387913
Piezo1 ion channels are mediators of mechanotransduction in several cell types including the vascular endothelium, renal tubular cells and erythrocytes. Gain-of-function mutations in PIEZO1 cause an autosomal dominant haemolytic anaemia...
10.
Cahalan S, Lukacs V, Ranade S, Chien S, Bandell M, Patapoutian A
Elife
. 2015 May;
4.
PMID: 26001274
Red blood cells (RBCs) experience significant mechanical forces while recirculating, but the consequences of these forces are not fully understood. Recent work has shown that gain-of-function mutations in mechanically activated...