Pedro Cutillas
Overview
Explore the profile of Pedro Cutillas including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
33
Citations
1028
Followers
0
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Recent Articles
11.
Freire-Beneitez V, Pomella N, Millner T, Dumas A, Niklison-Chirou M, Maniati E, et al.
NAR Cancer
. 2021 Jul;
3(1):zcab009.
PMID: 34316702
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component...
12.
Heward J, Konali L, DAvola A, Close K, Yeomans A, Philpott M, et al.
Blood
. 2021 Mar;
138(5):370-381.
PMID: 33786580
Loss-of-function mutations in KMT2D are a striking feature of germinal center (GC) lymphomas, resulting in decreased histone 3 lysine 4 (H3K4) methylation and altered gene expression. We hypothesized that inhibition...
13.
Edelmann J, Dokal A, Vilventhraraja E, Holzmann K, Britton D, Klymenko T, et al.
iScience
. 2021 Feb;
24(2):102089.
PMID: 33615197
The anti-CD20 monoclonal antibodies rituximab and obinutuzumab differ in their mechanisms of action, with obinutuzumab evoking greater direct B cell death. To characterize the signaling processes responsible for improved B...
14.
Xu R, Jones W, Wilcz-Villega E, Costa A, Rajeeve V, Bentham R, et al.
EMBO Rep
. 2020 Aug;
21(9):e48260.
PMID: 32783398
IκB kinase ε (IKKε) is a key molecule at the crossroads of inflammation and cancer. Known to regulate cytokine secretion via NFκB and IRF3, the kinase is also a breast...
15.
Patani H, Rushton M, Higham J, Teijeiro S, Oxley D, Cutillas P, et al.
Nat Commun
. 2020 Jul;
11(1):3671.
PMID: 32699299
Epigenetic reprogramming is a cancer hallmark, but how it unfolds during early neoplastic events and its role in carcinogenesis and cancer progression is not fully understood. Here we show that...
16.
Invergo B, Petursson B, Akhtar N, Bradley D, Giudice G, Hijazi M, et al.
Cell Syst
. 2020 May;
10(5):384-396.e9.
PMID: 32437683
Complex networks of regulatory relationships between protein kinases comprise a major component of intracellular signaling. Although many kinase-kinase regulatory relationships have been described in detail, these tend to be limited...
17.
Huang K, Reebye V, Czysz K, Ciriello S, Dorman S, Reccia I, et al.
Mol Ther Nucleic Acids
. 2019 Dec;
19:361-370.
PMID: 31877412
Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different signaling pathways are...
18.
Kostelnik K, Barker A, Schultz C, Mitchell T, Rajeeve V, White I, et al.
PLoS Biol
. 2019 Dec;
17(12):e3000554.
PMID: 31790392
Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte trafficking, vascular...
19.
Carvajal S, Perramon M, Casals G, Oro D, Ribera J, Morales-Ruiz M, et al.
Int J Mol Sci
. 2019 Dec;
20(23).
PMID: 31783479
Cerium oxide nanoparticles (CeONPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of...
20.
Roelens B, Barroso C, Montoya A, Cutillas P, Zhang W, Woglar A, et al.
Genetics
. 2019 Jul;
213(1):79-96.
PMID: 31345995
Proper partitioning of homologous chromosomes during meiosis relies on the coordinated execution of multiple interconnected events: Homologs must locate, recognize, and align with their correct pairing partners. Further, homolog pairing...