Torsten Wuestefeld
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Explore the profile of Torsten Wuestefeld including associated specialties, affiliations and a list of published articles.
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28
Citations
3072
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Recent Articles
1.
Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley C, et al.
Nat Cell Biol
. 2024 May;
26(6):1019.
PMID: 38778130
No abstract available.
2.
Liu X, Zhang K, Kaya N, Jia Z, Wu D, Chen T, et al.
Nat Commun
. 2024 Apr;
15(1):3169.
PMID: 38609353
Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-tumor heterogeneity (sITH) at the macroscopic (i.e., whole tumor) level is under-explored. Using a phylogeographic approach, we sequence...
3.
Zwirner S, Abu Rmilah A, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou A, et al.
Cell
. 2024 Mar;
187(7):1666-1684.e26.
PMID: 38490194
Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver...
4.
Iakovleva V, Wuestefeld A, Ong A, Gao R, Kaya N, Lee M, et al.
NPJ Regen Med
. 2023 Nov;
8(1):63.
PMID: 37935709
The liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing the accumulation of fibrotic tissue and leading to end-stage liver disease. Enhancing the...
5.
Hora S, Wuestefeld T
Cells
. 2023 Sep;
12(17).
PMID: 37681858
The liver is a complex organ with the ability to regenerate itself in response to injury. However, several factors can contribute to liver damage beyond repair. Liver injury can be...
6.
Lee Y, Lek C, Rong G, Wu Z, Shathishwaran S, Lee J, et al.
Theranostics
. 2023 Mar;
13(4):1370-1380.
PMID: 36923526
Tumor-initiating cells (TIC) often elude conventional cancer treatment, which results in metastasis and cancer relapse. Recently, studies have begun to focus on the TIC population in tumors to provide better...
7.
Yeo X, Tan L, Chae W, Lee D, Lee Y, Wuestefeld T, et al.
Front Neurosci
. 2023 Feb;
17:1123967.
PMID: 36816113
The liver partakes as a sensor and effector of peripheral metabolic changes and a regulator of systemic blood and nutrient circulation. As such, abnormalities arising from liver dysfunction can influence...
8.
Wuestefeld A, Iakovleva V, Yap S, Ong A, Huang D, Shuen T, et al.
Cancer Res
. 2022 Nov;
83(3):428-440.
PMID: 36449018
Significance: Liver damage induces a compensatory regenerative response that can drive premalignant to malignant transformation of senescent hepatocytes.
9.
Guerrero A, Innes A, Roux P, Buisman S, Jung J, Ortet L, et al.
Nat Aging
. 2022 Nov;
2:851-866.
PMID: 36438588
Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine...
10.
Kaya N, Chen J, Lai H, Yang H, Ma L, Liu X, et al.
Theranostics
. 2022 Jul;
12(10):4703-4717.
PMID: 35832070
Hepatocellular carcinoma (HCC) is one of the deadliest cancer types with diverse etiological factors across the world. Although large scale genomic studies have been conducted in different countries, integrative analysis...