Pawel Dobrzyn
Overview
Explore the profile of Pawel Dobrzyn including associated specialties, affiliations and a list of published articles.
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60
Citations
1240
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Recent Articles
1.
Sowka A, Balatskyi V, Navrulin V, Ntambi J, Dobrzyn P
J Cell Physiol
. 2025 Feb;
240(2):e31510.
PMID: 39943782
The dysregulation of perivascular adipose tissue (PVAT) is a key contributor to obesity-induced vascular dysfunction. Mouse periaortic adipose tissue is divided into two parts: thoracic perivascular adipose tissue (TPVAT) and...
2.
Piven O, Vaiciuleviciute R, Bernotiene E, Dobrzyn P
Acta Physiol (Oxf)
. 2025 Jan;
241(2):e14271.
PMID: 39801134
Direct cardiac reprogramming or transdifferentiation is a relatively new and promising area in regenerative therapy, cardiovascular disease modeling, and drug discovery. Effective reprogramming of fibroblasts is limited by their plasticity,...
3.
Strutynska N, Balatskyi V, B Strutynskyi R, Goshovska Y, Mys L, Luchkova A, et al.
Mitochondrion
. 2025 Jan;
81:102001.
PMID: 39755161
Pyridoxal-5-phosphate (PLP) enhances the synthesis of endogenous hydrogen sulfide, a potent regulator of cell metabolism. We used 24-month-old rats to investigate the PLP mitoprotective function in the aging heart. We...
4.
Wolosiewicz M, Balatskyi V, Duda M, Filip A, Ntambi J, Navrulin V, et al.
J Lipid Res
. 2024 Aug;
65(9):100612.
PMID: 39094772
Stearoyl-CoA desaturase (SCD) is a lipogenic enzyme that catalyzes formation of the first double bond in the carbon chain of saturated fatty acids. Four isoforms of SCD have been identified...
5.
B Strutynskyi R, Strutynska N, Piven O, Mys L, Goshovska Y, Fedichkina R, et al.
J Cardiovasc Pharmacol Ther
. 2023 Nov;
28:10742484231213175.
PMID: 37946524
The aging process is accompanied by the weakening of the protective systems of the organism, in particular by the decrease in the expression of ATP-sensitive potassium (K) channels and in...
6.
Olichwier A, Sowka A, Balatskyi V, Gan A, Dziewulska A, Dobrzyn P
Biochim Biophys Acta Mol Cell Res
. 2023 Oct;
1871(1):119608.
PMID: 37852324
Stearoyl-CoA desaturase 1 (SCD1) is an enzyme that is involved in the regulation of lipolysis in the heart. SCD1 also affects epigenetic mechanisms, such as DNA and histone modifications, in...
7.
Tracz-Gaszewska Z, Sowka A, Dobrzyn P
J Cell Physiol
. 2023 Oct;
238(12):2888-2903.
PMID: 37814830
Increases in fatty acid (FA) biosynthesis meet the higher lipid demand by intensely proliferating cancer cells and promoting their progression. Stearoyl-CoA desaturase 1 (SCD1) is the key enzyme in FA...
8.
Balatskyi V, Dobrzyn P
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982607
Stearoyl-CoA desaturase is a rate-limiting enzyme in the synthesis of monounsaturated fatty acids. Monounsaturated fatty acids limit the toxicity of exogenous saturated fats. Studies have shown that stearoyl-CoA desaturase 1...
9.
Balatskyi V, Sowka A, Dobrzyn P, Piven O
Acta Physiol (Oxf)
. 2023 Jan;
237(3):e13912.
PMID: 36599355
The WNT/β-catenin pathway is a master regulator of cardiac development and growth, and its activity is low in healthy adult hearts. However, even this low activity is essential for maintaining...
10.
Bednarski T, Duda M, Dobrzyn P
Cells
. 2022 Oct;
11(19).
PMID: 36230994
Disturbances in cardiac lipid metabolism are associated with the development of cardiac hypertrophy and heart failure. Spontaneously hypertensive rats (SHRs), a genetic model of primary hypertension and pathological left ventricular...