Pawel Borowiecki
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Explore the profile of Pawel Borowiecki including associated specialties, affiliations and a list of published articles.
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Recent Articles
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Bienzymatic Dynamic Kinetic Resolution of Secondary Alcohols by Esterification/Racemization in Water
Rudzka A, Reiter T, Kroutil W, Borowiecki P
Angew Chem Int Ed Engl
. 2024 Nov;
64(8):e202420133.
PMID: 39576712
Dynamic kinetic resolution (DKR) is a key method used to prepare optically pure compounds in 100 % theoretical yield starting from racemic substrates by combining the interconversion of substrate enantiomers...
3.
Bojarska J, Breza M, Borowiecki P, Madura I, Kaczmarek K, Ziora Z, et al.
R Soc Open Sci
. 2024 Oct;
11(10):40962.
PMID: 39386982
Conformational flexibility is one of the main disadvantages of peptide-based compounds. We focus on their molecular 'chameleonicity' related to forming pseudo-cyclic motifs via modulation of weak intramolecular interactions. It is...
4.
Zdun B, Borowiecki P
Chembiochem
. 2024 Jul;
25(20):e202400394.
PMID: 39031858
The reported chemoenzymatic strategy involves the employment of vinyl 3-(dimethylamino)propanoate as an irreversible acyl donor in a chromatography-free lipase-catalyzed kinetic resolution (KR) of racemic sec-alcohols. This biotransformation is achieved in...
5.
Rudzka A, Zdun B, Antos N, Montero L, Reiter T, Kroutil W, et al.
Commun Chem
. 2023 Oct;
6(1):217.
PMID: 37828252
Hydrogen transfer biocatalysts to prepare optically pure alcohols are in need, especially when it comes to sterically demanding ketones, whereof the bioreduced products are either essential precursors of pharmaceutically relevant...
6.
Winska P, Wielechowska M, Koronkiewicz M, Borowiecki P
Pharmaceutics
. 2023 Jul;
15(7).
PMID: 37514177
CK2 and PIM-1 are serine/threonine kinases involved in the regulation of many essential processes, such as proliferation, differentiation, and apoptosis. Inhibition of CK2 and PIM-1 kinase activity has been shown...
7.
Zdun B, Reiter T, Kroutil W, Borowiecki P
J Org Chem
. 2023 Jul;
88(15):11045-11055.
PMID: 37467462
We report on novel chemoenzymatic routes toward tenofovir using low-cost starting materials and commercial or homemade enzyme preparations as biocatalysts. The biocatalytic key step was accomplished either via stereoselective reduction...
8.
Zajda J, Borowiecki P, Matczuk M
Talanta
. 2023 Jun;
264:124749.
PMID: 37290334
The leading Pt(II)-based anticancer drugs have been used for decades; however, chemotherapy with their application is burdened with severe side effects. The administration of compounds capable of DNA platination in...
9.
Borowiecki P
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233106
To develop potent and safer analgesics, we designed and synthesized a novel enantiomerically enriched ethereal analog of (R)-iso-moramide, namely 2-[(2R)-2-(morpholin-4-yl)propoxy]-2,2-diphenyl-1-(pyrrolidin-1-yl)ethan-1-one. The titled active agent can potentially serve as a powerful...
10.
Borowiecki P, Zdun B, Popow N, Wiklinska M, Reiter T, Kroutil W
RSC Adv
. 2022 Aug;
12(34):22150-22160.
PMID: 36043081
Efficient chemoenzymatic routes toward the synthesis of both enantiomers of adrenergic β-blockers were accomplished by identifying a central chiral building block, which was first prepared using lipase-catalyzed kinetic resolution (KR,...