Pauline Beckers
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Explore the profile of Pauline Beckers including associated specialties, affiliations and a list of published articles.
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11
Citations
20
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Recent Articles
1.
Beckers P, Charlier M, Azria-Richter L, Richter L, Braconnier P, Desmet N, et al.
Neuropharmacology
. 2025 Jan;
269:110340.
PMID: 39889848
Background: Persistent inflammation leading to neuronal sensitization in pain pathways, are key features of chronic inflammatory pain. Alike macrophages in the periphery, glial cells exacerbate hypersensitivity by releasing proalgesic mediators...
2.
Beckers P, Belo Do Nascimento I, Charlier M, Desmet N, Massie A, Hermans E
J Neuroinflammation
. 2024 May;
21(1):117.
PMID: 38715127
Background: Despite the high prevalence of neuropathic pain, treating this neurological disease remains challenging, given the limited efficacy and numerous side effects associated with current therapies. The complexity in patient...
3.
Lara O, Janssen P, Mambretti M, De Pauw L, Ates G, Mackens L, et al.
Brain Behav Immun
. 2024 Mar;
118:275-286.
PMID: 38447884
xCT (Slc7a11), the specific subunit of the cystine/glutamate antiporter system x, is present in the brain and on immune cells, where it is known to modulate behavior and inflammatory responses....
4.
Beckers P, Doyen P, Hermans E
Cells
. 2024 Feb;
13(4.
PMID: 38391904
Acting as GTPase activating proteins promoting the silencing of activated G-proteins, regulators of G protein signaling (RGSs) are generally considered negative modulators of cell signaling. In the CNS, the expression...
5.
Belo Do Nascimento I, Ates G, Desmet N, Beckers P, Massie A, Hermans E
Biomolecules
. 2023 Aug;
13(8).
PMID: 37627248
Alterations in the activity of the regulator of cell metabolism AMP-activated protein kinase (AMPK) have been reported in motor neurons from patients and animal models of amyotrophic lateral sclerosis (ALS)....
6.
Hang T, Hung H, Beckers P, Desmet N, Lamrani M, Massie A, et al.
Front Mol Biosci
. 2022 Dec;
9:1064199.
PMID: 36533083
The cystine/glutamate antiporter system x (Sx ) belongs to the SLC7 family of plasma membrane transporters. It exports intracellular glutamate along the latter's concentration gradient as a driving force for...
7.
Belo Do Nascimento I, Verfaillie M, Ates G, Beckers P, Joris V, Desmet N, et al.
Cells
. 2022 Jun;
11(11).
PMID: 35681495
Energy homeostasis in the central nervous system largely depends on astrocytes, which provide metabolic support and protection to neurons. Astrocytes also ensure the clearance of extracellular glutamate through high-affinity transporters,...
8.
Verbruggen L, Ates G, Lara O, De Munck J, Villers A, De Pauw L, et al.
Mol Psychiatry
. 2022 Feb;
27(4):2355-2368.
PMID: 35181756
The cystine/glutamate antiporter system x has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, and genetic deletion of...
9.
Beckers P, Lara O, Belo Do Nascimento I, Desmet N, Massie A, Hermans E
Front Cell Neurosci
. 2022 Jan;
15:815771.
PMID: 35095428
Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases and has been frequently correlated with the altered expression and/or function of astrocytic high-affinity glutamate transporters. There is, however,...
10.
Ferraiolo M, Atik H, Ponthot R, Belo Do Nascimento I, Beckers P, Stove C, et al.
Eur J Pharmacol
. 2021 Oct;
911:174557.
PMID: 34626593
Chronic treatments with dopamine D2 receptor ligands induce fluctuations in D2 receptor density. Since D2 receptors tend to assemble as homodimers, we hypothesized that receptor density might influence constitutive and...