Olaya Lara
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Explore the profile of Olaya Lara including associated specialties, affiliations and a list of published articles.
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7
Citations
48
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Recent Articles
1.
Lara O, Janssen P, Mambretti M, De Pauw L, Ates G, Mackens L, et al.
Brain Behav Immun
. 2024 Mar;
118:275-286.
PMID: 38447884
xCT (Slc7a11), the specific subunit of the cystine/glutamate antiporter system x, is present in the brain and on immune cells, where it is known to modulate behavior and inflammatory responses....
2.
Pan Z, Van den Bossche J, Rodriguez-Aznar E, Janssen P, Lara O, Ates G, et al.
Cell Death Dis
. 2023 Aug;
14(8):536.
PMID: 37604805
Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the present...
3.
Verbruggen L, Ates G, Lara O, De Munck J, Villers A, De Pauw L, et al.
Mol Psychiatry
. 2022 Feb;
27(4):2355-2368.
PMID: 35181756
The cystine/glutamate antiporter system x has been identified as the major source of extracellular glutamate in several brain regions as well as a modulator of neuroinflammation, and genetic deletion of...
4.
Beckers P, Lara O, Belo Do Nascimento I, Desmet N, Massie A, Hermans E
Front Cell Neurosci
. 2022 Jan;
15:815771.
PMID: 35095428
Disruption of the glutamatergic homeostasis is commonly observed in neurological diseases and has been frequently correlated with the altered expression and/or function of astrocytic high-affinity glutamate transporters. There is, however,...
5.
Verbruggen L, Sprimont L, Bentea E, Janssen P, Gharib A, Deneyer L, et al.
Front Pharmacol
. 2021 Jun;
12:625699.
PMID: 34084129
Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system x in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this...
6.
Chellakkan Selvanesan B, Meena K, Beck A, Meheus L, Lara O, Rooman I, et al.
J Immunother Cancer
. 2020 Nov;
8(2).
PMID: 33154149
Background: Treatments for pancreatic ductal adenocarcinoma are poorly effective, at least partly due to the tumor's immune-suppressive stromal compartment. New evidence of positive effects on immune responses in the tumor...
7.
Bentea E, Villers A, Moore C, Funk A, ODonovan S, Verbruggen L, et al.
Mol Psychiatry
. 2020 May;
26(9):4754-4769.
PMID: 32366950
The astrocytic cystine/glutamate antiporter system x represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in...