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Paula Abou Karam

Explore the profile of Paula Abou Karam including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 447
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Recent Articles
1.
Fernandez-Becerra C, Xander P, Alfandari D, Dong G, Aparici-Herraiz I, Rosenhek-Goldian I, et al.
J Extracell Biol . 2024 Jun; 2(10):e117. PMID: 38939734
Parasites are responsible for the most neglected tropical diseases, affecting over a billion people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible for several millions...
2.
Nudelman A, Shenoy A, Allouche-Arnon H, Fisler M, Rosenhek-Goldian I, Dayan L, et al.
Biomedicines . 2024 Feb; 12(2). PMID: 38398037
Proteolysis of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) plays a crucial role in the immune response to bacterial infections. Here we report the secretion of MMPs associated with...
3.
Morandi M, Busko P, Ozer-Partuk E, Khan S, Zarfati G, Elbaz-Alon Y, et al.
PNAS Nexus . 2023 Jan; 1(4):pgac156. PMID: 36714848
Extracellular vesicles (EVs) transfer bioactive molecules between cells in a process reminiscent of enveloped viruses. EV cargo delivery is thought to occur by protein-mediated and pH-dependent membrane fusion of the...
4.
Galisova A, Zahradnik J, Allouche-Arnon H, Morandi M, Karam P, Fisler M, et al.
ACS Nano . 2022 Aug; 16(8):12276-12289. PMID: 35921522
The elucidation of viral-receptor interactions and an understanding of virus-spreading mechanisms are of great importance, particularly in the era of a pandemic. Indeed, advances in computational chemistry, synthetic biology, and...
5.
Rosenhek-Goldian I, Karam P, Regev-Rudzki N, Rojas A
Methods Mol Biol . 2022 Jul; 2470:133-145. PMID: 35881344
Malaria is one the most devastating infectious diseases in the world: of the five malaria-associated parasites, Plasmodium falciparum and P. vivax are the most pathogenic and widespread, respectively. P. falciparum...
6.
Karam P, Rosenhek-Goldian I, Ziv T, Ben Ami Pilo H, Azuri I, Rivkin A, et al.
EMBO Rep . 2022 Jun; 23(7):e54755. PMID: 35642585
Malaria is the most serious mosquito-borne parasitic disease, caused mainly by the intracellular parasite Plasmodium falciparum. The parasite invades human red blood cells and releases extracellular vesicles (EVs) to alter...
7.
Biram A, Liu J, Hezroni H, Davidzohn N, Schmiedel D, Khatib-Massalha E, et al.
Immunity . 2022 Feb; 55(3):442-458.e8. PMID: 35182483
Consecutive exposures to different pathogens are highly prevalent and often alter the host immune response. However, it remains unknown how a secondary bacterial infection affects an ongoing adaptive immune response...
8.
Alfandari D, Ben Ami Pilo H, Karam P, Dagan O, Joubran C, Rotkopf R, et al.
Front Cell Infect Microbiol . 2022 Feb; 11:739628. PMID: 35155269
Extracellular vesicles (EVs) are produced by across almost all the living kingdoms and play a crucial role in cell-cell communication processes. EVs are especially important for pathogens, as parasite, the...
9.
Ofir-Birin Y, Ben Ami Pilo H, Camacho A, Rudik A, Rivkin A, Revach O, et al.
Nat Commun . 2021 Aug; 12(1):4851. PMID: 34381047
Pathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium...
10.
Dekel E, Yaffe D, Rosenhek-Goldian I, Ben-Nissan G, Ofir-Birin Y, Morandi M, et al.
Nat Commun . 2021 Feb; 12(1):1172. PMID: 33608523
Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms, making them both a fascinating host cell, in general, and an intriguing choice for the deadly malaria parasite...