Paula A Bubulya
Overview
Explore the profile of Paula A Bubulya including associated specialties, affiliations and a list of published articles.
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13
Citations
1558
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Recent Articles
1.
Varia S, Cheedu D, Markey M, Torres-Shafer K, Battini V, Bubulya A, et al.
Int J Mol Sci
. 2017 Sep;
18(9).
PMID: 28895891
Serine-arginine-rich (SR) or SR-like splicing factors interact with exon junction complex proteins during pre-mRNA processing to promote mRNA packaging into mature messenger ribonucleoproteins (mRNPs) and to dictate mRNA stability, nuclear...
2.
Kim J, Shinde D, Reijnders M, Hauser N, Belmonte R, Wilson G, et al.
Am J Hum Genet
. 2016 Aug;
99(3):711-719.
PMID: 27545680
The overall understanding of the molecular etiologies of intellectual disability (ID) and developmental delay (DD) is increasing as next-generation sequencing technologies identify genetic variants in individuals with such disorders. However,...
3.
Battini V, Bubulya A, Bubulya P
Int J Mol Sci
. 2015 Mar;
16(3):5886-99.
PMID: 25782155
Pre-mRNA splicing requires proper splice site selection mediated by many factors including snRNPs and serine-arginine rich (SR) splicing factors. Our lab previously reported that the SR-like protein SON maintains organization...
4.
Lu X, Ng H, Bubulya P
Wiley Interdiscip Rev RNA
. 2014 May;
5(5):637-46.
PMID: 24789761
SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of...
5.
Lu X, Goke J, Sachs F, Jacques P, Liang H, Feng B, et al.
Nat Cell Biol
. 2013 Sep;
15(10):1141-1152.
PMID: 24013217
Human embryonic stem cells (hESCs) harbour the ability to undergo lineage-specific differentiation into clinically relevant cell types. Transcription factors and epigenetic modifiers are known to play important roles in the...
6.
Varia S, Potabathula D, Deng Z, Bubulya A, Bubulya P
Nucleus
. 2013 Jun;
4(3):229-40.
PMID: 23778535
Transcription of protein-coding genes in mammalian cells is coordinated with pre-mRNA processing as well as the assembly and nuclear export of mRNPs. Btf (BCLAF1) and TRAP150 (THRAP3) were previously reported...
7.
Leonard M, Hill N, Bubulya P, Kadakia M
Cell Cycle
. 2013 Apr;
12(9):1406-15.
PMID: 23574721
Loss of the tumor suppressor PTEN is observed in many human cancers that display increased chromosome instability and aneuploidy. The subcellular fractions of PTEN are associated with different functions that...
8.
Sharma A, Markey M, Torres-Munoz K, Varia S, Kadakia M, Bubulya A, et al.
J Cell Sci
. 2011 Dec;
124(Pt 24):4286-98.
PMID: 22193954
Serine-arginine-rich (SR) proteins play a key role in alternative pre-mRNA splicing in eukaryotes. We recently showed that a large SR protein called Son has unique repeat motifs that are essential...
9.
Tripathi V, Ellis J, Shen Z, Song D, Pan Q, Watt A, et al.
Mol Cell
. 2010 Aug;
39(6):925-38.
PMID: 20797886
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell-type-specific AS in a concentration-...
10.
Sharma A, Takata H, Shibahara K, Bubulya A, Bubulya P
Mol Biol Cell
. 2010 Jan;
21(4):650-63.
PMID: 20053686
Subnuclear organization and spatiotemporal regulation of pre-mRNA processing factors is essential for the production of mature protein-coding mRNAs. We have discovered that a large protein called Son has a novel...