Paul Taslimi
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Explore the profile of Paul Taslimi including associated specialties, affiliations and a list of published articles.
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10
Citations
264
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Recent Articles
1.
Yamada K, Levell J, Yoon T, Kohls D, Yowe D, Rigel D, et al.
J Med Chem
. 2017 Aug;
60(16):7099-7107.
PMID: 28771350
The observed structure-activity relationship of three distinct ATP noncompetitive With-No-Lysine (WNK) kinase inhibitor series, together with a crystal structure of a previously disclosed allosteric inhibitor bound to WNK1, led to...
2.
Green J, Cao J, Bandarage U, Gao H, Court J, Marhefka C, et al.
J Med Chem
. 2015 Jun;
58(12):5028-37.
PMID: 26039570
The Rho kinases (ROCK1 and ROCK2) are highly homologous serine/threonine kinases that act on substrates associated with cellular motility, morphology, and contraction and are of therapeutic interest in diseases associated...
3.
Duffy J, Harrington E, Salituro F, Cochran J, Green J, Gao H, et al.
ACS Med Chem Lett
. 2014 Jun;
2(10):758-63.
PMID: 24900264
The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme-ligand complexes guided the selection of screening compounds, leading to the identification...
4.
Brauchle M, Yao Z, Arora R, Thigale S, Clay I, Inverardi B, et al.
PLoS One
. 2013 Apr;
8(4):e60549.
PMID: 23593242
Histone modifications play an important role in chromatin organization and gene regulation, and their interpretation is referred to as epigenetic control. The methylation levels of several lysine residues in histone...
5.
Cao J, Gao H, Bemis G, Salituro F, Ledeboer M, Harrington E, et al.
Bioorg Med Chem Lett
. 2009 Apr;
19(10):2891-5.
PMID: 19361991
A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3. X-ray crystallographic structures aided in the design and synthesis of novel, selective compounds, that inhibit...
6.
Farmer L, Bemis G, Britt S, Cochran J, Connors M, Harrington E, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(23):6231-5.
PMID: 18938080
A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar K(i)'s against SYK and...
7.
Iyer G, Taslimi P, Pazhanisamy S
Anal Biochem
. 2007 Dec;
373(2):197-206.
PMID: 18047825
Staurosporine is a broad-spectrum inhibitor of both tyrosine and serine/threonine protein kinases. Excitation of staurosporine and its analogues at 296 nm results in major emission bands centered at 378 and...
8.
Bakhtiarova A, Taslimi P, Elliman S, Kosinski P, Hubbard B, Kavana M, et al.
Biochem Biophys Res Commun
. 2006 Oct;
351(2):481-4.
PMID: 17064666
The potential therapeutic value of resveratrol in age-related disease settings including cancer, diabetes, and Alzheimer's has emerged from a rapidly growing body of experimental evidence. Protection from oxidative stress appears...
9.
Jacobs M, Hayakawa K, Swenson L, Bellon S, Fleming M, Taslimi P, et al.
J Biol Chem
. 2005 Oct;
281(1):260-8.
PMID: 16249185
ROCK or Rho-associated kinase, a serine/threonine kinase, is an effector of Rho-dependent signaling and is involved in actin-cytoskeleton assembly and cell motility and contraction. The ROCK protein consists of several...
10.
Doran J, Liu X, Taslimi P, Saadat A, Fox T
Biochem J
. 2004 Aug;
384(Pt 2):255-62.
PMID: 15291762
The effect of the length of ROCK (Rho-associated kinase) on its oligomerization state has been investigated by analysing full-length protein and four truncated constructs using light-scattering and analytical ultracentrifugation methods....