Paul S Brookes
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Explore the profile of Paul S Brookes including associated specialties, affiliations and a list of published articles.
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132
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12721
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Recent Articles
1.
Casso-Chapa B, Vazquez Gonzalez N, Le N, Palaskas N, Nead K, Eutsey L, et al.
Arterioscler Thromb Vasc Biol
. 2025 Jan;
45(3):372-385.
PMID: 39817327
Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease,...
2.
Catheline S, Smith C, McArthur M, Yu C, Brookes P, Eliseev R
J Biol Chem
. 2024 Nov;
301(1):108016.
PMID: 39608710
Bioenergetic preferences of osteolineage cells, including osteoprogenitors and osteoblasts (OBs), are a matter of intense debate. Early studies pointed to OB reliance on glucose and aerobic glycolysis while more recent...
3.
Cohen E, Roethlin K, Yee M, Woeller C, Brookes P, Porter Jr G, et al.
Redox Biol
. 2024 Sep;
76:103351.
PMID: 39276392
Diastolic dysfunction is increasingly common in preterm infants exposed to supplemental oxygen (hyperoxia). Previous studies in neonatal mice showed hyperoxia suppresses fatty acid synthesis genes required for proliferation and survival...
4.
Faniyan T, Zhang X, Morgan D, Robles J, Bathina S, Brookes P, et al.
Elife
. 2024 Jul;
12.
PMID: 39082939
The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset...
5.
Jeon K, Kumar A, Brookes P, Nehrke K, Huxlin K
Redox Biol
. 2024 Jun;
75:103235.
PMID: 38889622
Myofibroblasts are key cellular effectors of corneal wound healing from trauma, surgery, or infection. However, their persistent deposition of disorganized extracellular matrix can also cause corneal fibrosis and visual impairment....
6.
Beutner G, Burris J, Collins M, Kulkarni C, Nadtochiy S, Bentley K, et al.
iScience
. 2024 Feb;
27(3):109157.
PMID: 38414851
In the embryonic heart, the activation of the mitochondrial electron transport chain (ETC) coincides with the closure of the cyclophilin D (CypD) regulated mitochondrial permeability transition pore (mPTP). However, it...
7.
Tabata Fukushima C, Dancil I, Clary H, Shah N, Nadtochiy S, Brookes P
Redox Biol
. 2024 Jan;
70:103047.
PMID: 38295577
Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In isolated mitochondria with succinate as...
8.
Tabata Fukushima C, Dancil I, Clary H, Shah N, Nadtochiy S, Brookes P
bioRxiv
. 2023 Dec;
PMID: 38045326
Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In isolated mitochondria with succinate as...
9.
Mia S, Sonkar R, Williams L, Latimer M, Rawnsley D, Rana S, et al.
JACC Basic Transl Sci
. 2023 Oct;
8(9):1141-1156.
PMID: 37791313
Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that,...
10.
Faniyan T, Zhang X, Morgan D, Robles J, Bathina S, Brookes P, et al.
bioRxiv
. 2023 Oct;
PMID: 37790458
The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset...