William R Urciuoli
Overview
Explore the profile of William R Urciuoli including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
250
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Recent Articles
1.
Wojtovich A, Smith C, Urciuoli W, Wang Y, Xia X, Brookes P, et al.
Anesthesiology
. 2016 Feb;
124(5):1065-76.
PMID: 26845140
Background: Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve...
2.
Zhang J, Nadtochiy S, Urciuoli W, Brookes P
Am J Physiol Heart Circ Physiol
. 2015 Nov;
310(1):H29-38.
PMID: 26519034
Mitochondrial quality control mechanisms have been implicated in protection against cardiac ischemia-reperfusion (IR) injury. Previously, cloxyquin (5-chloroquinolin-8-ol) was identified via phenotypic screening as a cardioprotective compound. Herein, cloxyquin was identified...
3.
Porter G, Urciuoli W, Brookes P, Nadtochiy S
Am J Physiol Heart Circ Physiol
. 2014 Apr;
306(12):H1602-9.
PMID: 24748594
Ischemia-reperfusion (IR) injury is significantly worse in aged hearts, but the underlying mechanisms are poorly understood. Age-related damage to mitochondria may be a critical feature, which manifests in an exacerbation...
4.
Wojtovich A, Nadtochiy S, Urciuoli W, Smith C, Grunnet M, Nehrke K, et al.
PeerJ
. 2013 May;
1:e48.
PMID: 23638385
Opening of BK-type Ca(2+) activated K(+) channels protects the heart against ischemia-reperfusion (IR) injury. However, the location of BK channels responsible for cardioprotection is debated. Herein we confirmed that openers...
5.
Wojtovich A, Urciuoli W, Chatterjee S, Fisher A, Nehrke K, Brookes P
Am J Physiol Heart Circ Physiol
. 2013 Apr;
304(11):H1439-45.
PMID: 23585131
ATP-sensitive K(+) (KATP) channels that contain K(+) inward rectifier subunits of the 6.2 isotype (Kir6.2) are important regulators of the cardiac response to ischemia-reperfusion (I/R) injury. Opening of these channels...
6.
Guo S, Olm-Shipman A, Walters A, Urciuoli W, Devito S, Nadtochiy S, et al.
Circ Res
. 2012 Mar;
110(7):948-57.
PMID: 22394516
Rationale: Tissue ischemia/reperfusion (IR) injury underlies several leading causes of death such as heart-attack and stroke. The lack of clinical therapies for IR injury may be partly due to the...
7.
Wojtovich A, Sherman T, Nadtochiy S, Urciuoli W, Brookes P, Nehrke K
PLoS One
. 2011 Dec;
6(12):e28287.
PMID: 22145034
Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure to volatile...