Paul R Mittelstadt
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Explore the profile of Paul R Mittelstadt including associated specialties, affiliations and a list of published articles.
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21
Citations
747
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Recent Articles
1.
Mittelstadt P, Taves M, Ashwell J
J Immunol
. 2019 Sep;
203(8):2163-2170.
PMID: 31527196
Glucocorticoid (GC) signaling in thymocytes shapes the TCR repertoire by antagonizing thymocyte negative selection. The transcription factors Nur77 and Helios, which are upregulated in TCR-signaled thymocytes, have been implicated in...
2.
Taves M, Mittelstadt P, Presman D, Hager G, Ashwell J
Cell Rep
. 2019 Mar;
26(13):3629-3642.e4.
PMID: 30917317
Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid signaling...
3.
Mittelstadt P, Taves M, Ashwell J
J Immunol
. 2018 Feb;
200(6):1988-1994.
PMID: 29440508
Glucocorticoid (GC) signaling in thymocytes counters negative selection and promotes the generation of a self-tolerant yet Ag-responsive T cell repertoire. Whereas circulating GC are derived from the adrenals, GC are...
4.
Giardino Torchia M, Dutta D, Mittelstadt P, Guha J, Gaida M, Fish K, et al.
Proc Natl Acad Sci U S A
. 2018 Feb;
115(9):2174-2179.
PMID: 29440413
ZAP-70 is a tyrosine kinase that is essential for initiation of T cell antigen receptor (TCR) signaling. We have found that T cell p38 MAP kinase (MAPK), which is directly...
5.
Dutta D, Barr V, Akpan I, Mittelstadt P, Singha L, Samelson L, et al.
Nat Immunol
. 2016 Dec;
18(2):196-204.
PMID: 27941787
Calcineurin is a phosphatase whose primary targets in T cells are NFAT transcription factors, and inhibition of calcineurin activity by treatment with cyclosporin A (CsA) or FK506 is a cornerstone...
6.
Kugler D, Flomerfelt F, Costa D, Laky K, Kamenyeva O, Mittelstadt P, et al.
J Exp Med
. 2016 Nov;
213(13):3041-3056.
PMID: 27849554
Because antigen-stimulated naive T cells either die as effectors or enter the activated/memory pool, continuous egress of new T lymphocytes from thymus is essential for maintenance of peripheral immune homeostasis....
7.
Solano M, Holmes M, Mittelstadt P, Chapman K, Tolosa E
Semin Immunopathol
. 2016 Jul;
38(6):739-763.
PMID: 27465226
Endogenous levels of glucocorticoids rise during pregnancy to warrant development and maturation of the fetal organs close to birth. However, during most of the gestation, the fetus is protected from...
8.
Meena N, Zhu G, Mittelstadt P, Giardino Torchia M, Pourcelot M, Arnoult D, et al.
FEBS Lett
. 2016 Apr;
590(10):1498-508.
PMID: 27086836
Pathogen-associated molecular pattern (PAMP) recognition leads to TANK-binding kinase (TBK1) polyubiquitination and activation by transautophosphorylation, resulting in IFN-β production. Here, we describe a mouse model of optineurin insufficiency (OptnΔ(157) )...
9.
Li C, Munitic I, Mittelstadt P, Castro E, Ashwell J
PLoS Biol
. 2015 Oct;
13(10):e1002269.
PMID: 26440998
Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed...
10.
Presman D, Ogara M, Stortz M, Alvarez L, Pooley J, Schiltz R, et al.
PLoS Biol
. 2014 Mar;
12(3):e1001813.
PMID: 24642507
Glucocorticoids are essential for life, but are also implicated in disease pathogenesis and may produce unwanted effects when given in high doses. Glucocorticoid receptor (GR) transcriptional activity and clinical outcome...