Paul L Hallenbeck
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Explore the profile of Paul L Hallenbeck including associated specialties, affiliations and a list of published articles.
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11
Citations
658
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Recent Articles
1.
Liu Z, Zhao X, Mao H, Baxter P, Huang Y, Yu L, et al.
Neuro Oncol
. 2013 May;
15(9):1173-85.
PMID: 23658322
Background: Seneca Valley virus (SVV-001) is a nonpathogenic oncolytic virus that can be systemically administered and can pass through the blood-brain barrier. We examined its therapeutic efficacy and the mechanism...
2.
Poirier J, Reddy P, Idamakanti N, Li S, Stump K, Burroughs K, et al.
J Gen Virol
. 2012 Sep;
93(Pt 12):2606-2613.
PMID: 22971818
Seneca Valley virus (SVV-001) is an oncolytic picornavirus with selective tropism for a subset of human cancers with neuroendocrine differentiation. To characterize further the specificity of SVV-001 and its patterns...
3.
Willcocks M, Locker N, Gomwalk Z, Royall E, Bakhshesh M, Belsham G, et al.
J Virol
. 2011 Feb;
85(9):4452-61.
PMID: 21325406
The RNA genome of Seneca Valley virus (SVV), a recently identified picornavirus, contains an internal ribosome entry site (IRES) element which has structural and functional similarity to that from classical...
4.
Rudin C, Poirier J, Senzer N, Stephenson Jr J, Loesch D, Burroughs K, et al.
Clin Cancer Res
. 2011 Feb;
17(4):888-95.
PMID: 21304001
Purpose: Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer. We conducted a...
5.
Yu L, Baxter P, Zhao X, Liu Z, Wadhwa L, Zhang Y, et al.
Neuro Oncol
. 2010 Nov;
13(1):14-27.
PMID: 21075780
Difficulties of drug delivery across the blood-brain barrier (BBB) and failure to eliminate cancer stem cells (CSCs) are believed to be the major causes of tumor recurrences in children with...
6.
Venkataraman S, Reddy S, Loo J, Idamakanti N, Hallenbeck P, Reddy V
Structure
. 2008 Oct;
16(10):1555-61.
PMID: 18940610
The crystal structure of Seneca Valley Virus-001 (SVV-001), the representative member of a new genus, Senecavirus, is reported at 2.3A resolution. SVV-001 is the first naturally occurring nonpathogenic picornavirus shown...
7.
Hales L, Knowles N, Reddy P, Xu L, Hay C, Hallenbeck P
J Gen Virol
. 2008 Apr;
89(Pt 5):1265-1275.
PMID: 18420805
The complete genome sequence of Seneca Valley virus-001 (SVV-001), a small RNA virus, was determined and was shown to have typical picornavirus features. The 7280 nt long genome was predicted...
8.
Venkataraman S, Reddy S, Loo J, Idamakanti N, Hallenbeck P, Reddy V
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2008 Apr;
64(Pt 4):293-6.
PMID: 18391430
Seneca Valley Virus-001 (SVV-001) is a newly found species in the Picornaviridae family. SVV-001 is the first naturally occurring nonpathogenic picornavirus observed to mediate selective cytotoxicity towards tumor cells with...
9.
Reddy P, Burroughs K, Hales L, Ganesh S, Jones B, Idamakanti N, et al.
J Natl Cancer Inst
. 2007 Nov;
99(21):1623-33.
PMID: 17971529
Background: Numerous clinical trials have demonstrated that oncolytic viruses can elicit antitumor responses when they are administered directly into localized cancers. However, the treatment of metastatic disease with oncolytic viruses...
10.
Ryan P, Jakubczak J, Stewart D, Hawkins L, Cheng C, Clarke L, et al.
Cancer Gene Ther
. 2004 Jul;
11(8):555-69.
PMID: 15232601
A potentially promising treatment of metastatic cancer is the systemic delivery of oncolytic adenoviruses. This requires engineering viruses which selectively replicate in tumors. We have constructed such an oncolytic adenovirus,...