Paul J Beswick
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Explore the profile of Paul J Beswick including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
112
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0
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Recent Articles
11.
Beswick P, Blackaby A, Bountra C, Brown T, Browning K, Campbell I, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(15):4509-14.
PMID: 19523822
Many years of work have been invested in the identification of potent and selective COX-2 inhibitors for the treatment of chronic inflammatory pain. One issue faced by workers is the...
12.
Swarbrick M, Beswick P, Gleave R, Green R, Bingham S, Bountra C, et al.
Bioorg Med Chem Lett
. 2009 Jun;
19(15):4504-8.
PMID: 19520573
A novel series of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidine-based cyclooxygenase-2 (COX-2) inhibitors, which have a different arrangement of substituents compared to the more common 1,2-diarylheterocycle based molecules, have been discovered. For example, 2-(butyloxy)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (47),...
13.
Bingham S, Beswick P, Blum D, Gray N, Chessell I
Semin Cell Dev Biol
. 2006 Oct;
17(5):544-54.
PMID: 17071117
Cycloxygenase (COX) pathways have long been targeted for the treatment of inflammatory pain, initially through the use of NSAIDs. With the demonstration of two major COX isoforms, COX-1 and COX-2,...
14.
Bingham S, Beswick P, Bountra C, Brown T, Campbell I, Chessell I, et al.
J Pharmacol Exp Ther
. 2004 Dec;
312(3):1161-9.
PMID: 15572651
The pathogenic form of the cyclooxygenase (COX) enzyme, COX-2, is also constitutively present in the spinal cord and has been implicated in chronic pain states in rat and man. A...
15.
Willis M, McNally S, Beswick P
Angew Chem Int Ed Engl
. 2004 Jan;
43(3):340-3.
PMID: 14705092
No abstract available.