Sadhana Patel
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Explore the profile of Sadhana Patel including associated specialties, affiliations and a list of published articles.
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16
Citations
550
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Recent Articles
1.
Feldman G, Sousa A, Lipson D, Tombs L, Barnes N, Riley J, et al.
Adv Ther
. 2017 Nov;
34(11):2518-2533.
PMID: 29094315
Introduction: We report the results of the first direct comparison of the once-daily fixed-dose long-acting muscarinic antagonist/long-acting β-agonist (LAMA/LABA) combinations umeclidinium/vilanterol (UMEC/VI) and tiotropium/olodaterol (TIO/OLO) in patients with COPD. Methods:...
2.
Abberley L, Bebius A, Beswick P, Billinton A, Collis K, Dean D, et al.
Bioorg Med Chem Lett
. 2010 Oct;
20(22):6370-4.
PMID: 20934331
A backup molecule to compound 2 was sought by targeting the most likely metabolically vulnerable site in this molecule. Compound 18 was subsequently identified as a potent P2X(7) antagonist with...
3.
Abdi M, Beswick P, Billinton A, Chambers L, Charlton A, Collins S, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(17):5080-4.
PMID: 20673717
A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X(7) receptor antagonist. Structure-activity relationships (SAR) of a series of pyroglutamic acid amide analogues of 4 were investigated and...
4.
Beswick P, Billinton A, Chambers L, Dean D, Fonfria E, Gleave R, et al.
Bioorg Med Chem Lett
. 2010 Jun;
20(15):4653-6.
PMID: 20579878
Structure-activity relationships (SAR) of analogues of lead compound 1 were investigated and compound 16 was selected for further study in animal models of pain. Compound 16 was shown to be...
5.
Gleave R, Beswick P, Brown A, Giblin G, Goldsmith P, Haslam C, et al.
Bioorg Med Chem Lett
. 2009 Dec;
20(2):465-8.
PMID: 20005703
A series of 3-amino-6-aryl-pyridazines have been identified as CB(2) agonists with high efficacy and selectivity against the CB(1) receptor. Details of the investigation of structure-activity relationships (SAR) are disclosed, which...
6.
Hall A, Billinton A, Brown S, Chowdhury A, Giblin G, Goldsmith P, et al.
Bioorg Med Chem Lett
. 2008 Apr;
18(8):2684-90.
PMID: 18378447
We describe the medicinal chemistry approach that generated a novel indole series of EP(1) receptor antagonists. The SAR of this new template was evaluated and culminated in the identification of...
7.
Barclay J, Clark A, Ganju P, Gentry C, Patel S, Wotherspoon G, et al.
Pain
. 2007 Jan;
130(3):225-234.
PMID: 17250968
Using a gene expression analysis approach we found that the mRNA encoding the lysosomal cysteine protease cathepsin S (CatS) was up-regulated in rat dorsal root ganglia (DRG) following peripheral nerve...
8.
Culshaw A, Bevan S, Christiansen M, Copp P, Davis A, Davis C, et al.
J Med Chem
. 2006 Jan;
49(2):471-4.
PMID: 16420034
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage. Blockers of this channel may...
9.
Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt F, et al.
Nucleic Acids Res
. 2004 Mar;
32(5):e49.
PMID: 15026538
Double stranded, short interfering RNAs (siRNA) of 21-22 nt length initiate a sequence-specific, post-trancriptional gene silencing in animals and plants known as RNA interference (RNAi). Here we show that RNAi...
10.
Fox A, Gentry C, Patel S, Kesingland A, Bevan S
Pain
. 2003 Sep;
105(1-2):355-62.
PMID: 14499454
Anti-epileptic drugs (AEDs) are increasingly used for the treatment of neuropathic pain. Oxcarbazepine is a recently introduced AED that is effective in treating epilepsy and has an improved side-effect profile...