Paul Horrocks
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Explore the profile of Paul Horrocks including associated specialties, affiliations and a list of published articles.
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41
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1102
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Recent Articles
1.
Okokon J, Mobley R, Edem U, Bassey A, Fadayomi I, Drijfhout F, et al.
Sci Rep
. 2022 Jun;
12(1):10250.
PMID: 35715548
Saccharum officinarum Linn. (sugarcane, Family-Poaceae) is employed in Ibibio traditional medicine for the treatment of various infections and diseases such as malaria. We This study aims to assess the antiplasmodial...
2.
Luo J, Mobley R, Woodfine S, Drijfhout F, Horrocks P, Ren X, et al.
Appl Microbiol Biotechnol
. 2022 Mar;
106(7):2433-2444.
PMID: 35355096
Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate...
3.
Uche F, Guo X, Okokon J, Ullah I, Horrocks P, Boateng J, et al.
Antimicrob Agents Chemother
. 2020 Dec;
65(2).
PMID: 33257443
Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the antiplasmodial activity of three BBIQ alkaloids (cycleanine [compound 1],...
4.
Czechowski T, Rinaldi M, Famodimu M, Van Veelen M, Larson T, Winzer T, et al.
Front Plant Sci
. 2019 Aug;
10:984.
PMID: 31417596
Artemisinin, a sesquiterpene lactone produced by glandular secretory trichomes, is the active ingredient in the most effective treatment for uncomplicated malaria caused by parasites. Other metabolites in or related species,...
5.
Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis
Aldulaimi O, Drijfhout F, Uche F, Horrocks P, Li W
BMC Complement Altern Med
. 2019 Jul;
19(1):183.
PMID: 31340805
Background: Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts showed potent...
6.
Berry S, Hameed H, Thomason A, Maciej-Hulme M, Abou-Akkada S, Horrocks P, et al.
PLoS Negl Trop Dis
. 2018 Jul;
12(7):e0006639.
PMID: 30001317
The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer,...
7.
Johnson-Ajinwo O, Ullah I, Mbye H, Richardson A, Horrocks P, Li W
Bioorg Med Chem Lett
. 2018 Mar;
28(7):1219-1222.
PMID: 29519737
Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the...
8.
Harris L, Monsell K, Noulin F, Famodimu M, Smargiasso N, Damblon C, et al.
Antimicrob Agents Chemother
. 2018 Jan;
62(3).
PMID: 29311059
G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and...
9.
Boyle M, Skidmore M, Dickerman B, Cooper L, Devlin A, Yates E, et al.
Antimicrob Agents Chemother
. 2017 Sep;
61(11).
PMID: 28893781
Despite recent successful control efforts, malaria remains a leading global health burden. Alarmingly, resistance to current antimalarials is increasing and the development of new drug families is needed to maintain...
10.
Aldulaimi O, Uche F, Hameed H, Mbye H, Ullah I, Drijfhout F, et al.
J Ethnopharmacol
. 2017 Jan;
198:221-225.
PMID: 28089716
Ethnopharmacological Relevance And Aim: A decoction of the bark of Cylicodiscus gabunensis Harms is used as a traditional medicine in the treatment of malaria in Nigeria. This study aims to...