Paul Hollingworth
Overview
Explore the profile of Paul Hollingworth including associated specialties, affiliations and a list of published articles.
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37
Citations
6147
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Recent Articles
1.
Kunkle B, Grenier-Boley B, Sims R, Bis J, Damotte V, Naj A, et al.
Nat Genet
. 2019 Aug;
51(9):1423-1424.
PMID: 31417202
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
2.
Kunkle B, Grenier-Boley B, Sims R, Bis J, Damotte V, Naj A, et al.
Nat Genet
. 2019 Mar;
51(3):414-430.
PMID: 30820047
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed...
3.
Escott-Price V, Bellenguez C, Wang L, Choi S, Harold D, Jones L, et al.
PLoS One
. 2014 Jun;
9(6):e94661.
PMID: 24922517
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought...
4.
Chapman J, Rees E, Harold D, Ivanov D, Gerrish A, Sims R, et al.
Hum Mol Genet
. 2012 Nov;
22(4):816-24.
PMID: 23148125
We assessed the role of rare copy number variants (CNVs) in Alzheimer's disease (AD) using intensity data from 3260 AD cases and 1290 age-matched controls from the genome-wide association study...
5.
Proitsi P, Lupton M, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, et al.
Neurobiol Aging
. 2012 Feb;
33(8):1843.e9-17.
PMID: 22300950
Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to...
6.
Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, et al.
J Alzheimers Dis
. 2011 Oct;
28(2):377-87.
PMID: 22027014
Rare mutations in AβPP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We...
7.
Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2011 Aug;
156B(7):764-71.
PMID: 21812096
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal...
8.
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J, Carrasquillo M, et al.
Nat Genet
. 2011 Apr;
43(5):429-35.
PMID: 21460840
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in...
9.
Lupton M, Proitsi P, Danillidou M, Tsolaki M, Hamilton G, Wroe R, et al.
PLoS One
. 2011 Mar;
6(2):e17298.
PMID: 21364883
Nicastrin is an obligatory component of the γ-secretase; the enzyme complex that leads to the production of Aβ fragments critically central to the pathogenesis of Alzheimer's disease (AD). Analyses of...
10.
Reitz C, Cheng R, Rogaeva E, Lee J, Tokuhiro S, Zou F, et al.
Arch Neurol
. 2011 Jan;
68(1):99-106.
PMID: 21220680
Objective: To reexamine the association between the neuronal sortilin-related receptor gene (SORL1) and Alzheimer disease (AD). Design: Comprehensive and unbiased meta-analysis of all published and unpublished data from case-control studies...