Paul G Whitney
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Explore the profile of Paul G Whitney including associated specialties, affiliations and a list of published articles.
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28
Citations
2207
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Recent Articles
1.
Gressier E, Schulte-Schrepping J, Petrov L, Brumhard S, Stubbemann P, Hiller A, et al.
Nat Immunol
. 2023 May;
24(6):979-990.
PMID: 37188942
Antiviral CD8 T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we...
2.
Dahling S, Mansilla A, Knopper K, Grafen A, Utzschneider D, Ugur M, et al.
Immunity
. 2022 Apr;
55(4):656-670.e8.
PMID: 35366396
Reinvigoration of exhausted CD8 T (Tex) cells by checkpoint immunotherapy depends on the activation of precursors of exhausted T (Tpex) cells, but the local anatomical context of their maintenance, differentiation,...
3.
Jiang W, Wong J, Tan H, Kelly H, Whitney P, Barr I, et al.
Sci Rep
. 2021 Jan;
11(1):1864.
PMID: 33479388
The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the pre-clinical assessment of vaccines. However, relatively little is known about...
4.
Bachem A, Makhlouf C, Binger K, de Souza D, Tull D, Hochheiser K, et al.
Immunity
. 2019 Jul;
51(2):285-297.e5.
PMID: 31272808
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the impact of the microbiota on CD8 T cell memory. Antigen-activated...
5.
Harpur C, Kato Y, Dewi S, Stankovic S, Johnson D, Bedoui S, et al.
J Immunol
. 2019 Jan;
202(3):653-663.
PMID: 30598513
CD4 T cell responses are crucial for the control of many intracellular pathogens, yet the requirements for their induction are not fully understood. To better understand the role that various...
6.
Whitney P, Bar E, Osorio F, Rogers N, Schraml B, Deddouche S, et al.
PLoS Pathog
. 2018 Nov;
14(11):e1007366.
PMID: 30462735
[This corrects the article DOI: 10.1371/journal.ppat.1004276.].
7.
Benoun J, Peres N, Wang N, Pham O, Rudisill V, Fogassy Z, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):10416-10421.
PMID: 30254173
While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of Th1 cells is insufficient to protect against infection. Using an epitope-tagged vaccine strain of , we...
8.
Whitney P, Makhlouf C, MacLeod B, Ma J, Gressier E, Greyer M, et al.
J Virol
. 2017 Nov;
92(3).
PMID: 29142130
Resolution of virus infections depends on the priming of virus-specific CD8 T cells by dendritic cells (DC). While this process requires major histocompatibility complex (MHC) class I-restricted antigen presentation by...
9.
Sekiya T, Yamagishi J, Gray J, Whitney P, Martinelli A, Zeng W, et al.
Biomaterials
. 2017 May;
137:61-72.
PMID: 28544973
The lipopeptide RPamCys is an agonist for toll-like receptor-2 (TLR2), a key pathogen-associated molecular pattern receptor expressed on many antigen-presenting cells such as dendritic cells (DCs). Electrostatic association of RPamCys...
10.
Greyer M, Whitney P, Stock A, Davey G, Tebartz C, Bachem A, et al.
Cell Rep
. 2016 Jan;
14(3):586-597.
PMID: 26774484
DCs often require stimulation from CD4(+) T cells to propagate CD8(+) T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why this appears...