Paul G Hitchen
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Explore the profile of Paul G Hitchen including associated specialties, affiliations and a list of published articles.
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38
Citations
1790
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Recent Articles
1.
Duncombe L, Howells L, Haughey A, Taylor A, Kaveh D, Erdenlig Gyrbilek S, et al.
Microorganisms
. 2022 Apr;
10(4).
PMID: 35456759
Brucellosis is a global disease and the world's most prevalent zoonosis. All cases in livestock and most cases in humans are caused by members of the genus that possess a...
2.
Wu G, Hitchen P, Panico M, North S, Barbouche M, Binet D, et al.
Glycoconj J
. 2015 Dec;
33(3):447-56.
PMID: 26687240
Glycans serve as important regulators of antibody activities and half-lives. IgE is the most heavily glycosylated antibody, but in comparison to other antibodies little is known about its glycan structure...
3.
Leung M, Hitchen P, Ward D, Messer A, Marston S
J Biol Chem
. 2012 Dec;
288(7):4891-8.
PMID: 23271734
We studied O-linked β-N-acetylglucosamine (O-GlcNAc) modification of contractile proteins in human heart using SDS-PAGE and three detection methods: specific enzymatic conjugation of O-GlcNAc with UDP-N-azidoacetylgalactosamine (UDP-GalNAz) that is then linked...
4.
Sternberg M, Tamaddoni-Nezhad A, Lesk V, Kay E, Hitchen P, Cootes A, et al.
J Mol Biol
. 2012 Oct;
425(1):186-97.
PMID: 23103756
Increasingly, experimental data on biological systems are obtained from several sources and computational approaches are required to integrate this information and derive models for the function of the system. Here,...
5.
Harrison R, Hitchen P, Panico M, Morris H, Mekhaiel D, Pleass R, et al.
Glycobiology
. 2012 Jan;
22(5):662-75.
PMID: 22241827
α-Dystroglycan (DG) is a key component of the dystrophin-glycoprotein complex. Aberrant glycosylation of the protein has been linked to various forms of congenital muscular dystrophy. Unusually α-DG has previously been...
6.
Silva J, Lelianova V, Ermolyuk Y, Vysokov N, Hitchen P, Berninghausen O, et al.
Proc Natl Acad Sci U S A
. 2011 Jul;
108(29):12113-8.
PMID: 21724987
Latrophilin 1 (LPH1), a neuronal receptor of α-latrotoxin, is implicated in neurotransmitter release and control of presynaptic Ca(2+). As an "adhesion G-protein-coupled receptor," LPH1 can convert cell surface interactions into...
7.
Graham S, Antonopoulos A, Hitchen P, Haslam S, Dell A, Drickamer K, et al.
J Biol Chem
. 2011 May;
286(27):24336-49.
PMID: 21561871
The scavenger receptor C-type lectin (SRCL) is a glycan-binding receptor that has the capacity to mediate endocytosis of glycoproteins carrying terminal Lewis(x) groups (Galβ1-4(Fucα1-3)GlcNAc). A screen for glycoprotein ligands for...
8.
Powlesland A, Barrio M, Mordoh J, Hitchen P, Dell A, Drickamer K, et al.
BMC Biochem
. 2011 Mar;
12:13.
PMID: 21435201
Background: The Lewisx trisaccharide, also referred to as the CD15 antigen, is a diagnostic marker used to distinguish Hodgkin's lymphoma from other lymphocytic cancers. However, the role of such fucosylated...
9.
Peyfoon E, Meyer B, Hitchen P, Panico M, Morris H, Haslam S, et al.
Archaea
. 2010 Oct;
2010.
PMID: 20936123
Glycosylation of the S-layer of the crenarchaea Sulfolobus acidocaldarius has been investigated using glycoproteomic methodologies. The mature protein is predicted to contain 31 N-glycosylation consensus sites with approximately one third...
10.
Hitchen P, Twigger K, Valiente E, Langdon R, Wren B, Dell A
Biochem Soc Trans
. 2010 Sep;
38(5):1307-13.
PMID: 20863304
With glycosylation now firmly established across both Archaeal and bacterial proteins, a wide array of glycan diversity has become evident from structural analysis and genomic data. These discoveries have been...