Paul E M Phillips
Overview
Explore the profile of Paul E M Phillips including associated specialties, affiliations and a list of published articles.
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77
Citations
6926
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Recent Articles
21.
Hollon N, Arnold M, Gan J, Walton M, Phillips P
Proc Natl Acad Sci U S A
. 2014 Dec;
111(51):18357-62.
PMID: 25489094
Phasic dopamine transmission is posited to act as a critical teaching signal that updates the stored (or "cached") values assigned to reward-predictive stimuli and actions. It is widely hypothesized that...
22.
Goertz R, Wanat M, Gomez J, Brown Z, Phillips P, Paladini C
Neuropsychopharmacology
. 2014 Nov;
40(5):1151-62.
PMID: 25374094
Cocaine reinforcement is mediated by increased extracellular dopamine levels in the forebrain. This neurochemical effect was thought to require inhibition of dopamine reuptake, but cocaine is still reinforcing even in...
23.
Hart A, Clark J, Phillips P
Neurobiol Learn Mem
. 2014 Aug;
117:84-92.
PMID: 25172480
Cue- and reward-evoked phasic dopamine activity during Pavlovian and operant conditioning paradigms is well correlated with reward-prediction errors from formal reinforcement learning models, which feature teaching signals in the form...
24.
Willuhn I, Tose A, Wanat M, Hart A, Hollon N, Phillips P, et al.
J Neurosci
. 2014 Aug;
34(32):10616-23.
PMID: 25100595
Rats emit ultrasonic vocalizations (USVs) that are thought to serve as situation-dependent affective signals and accomplish important communicative functions. In appetitive situations, rats produce 50 kHz USVs, whereas 22 kHz...
25.
Ehrich J, Phillips P, Chavkin C
Neuropsychopharmacology
. 2014 Jun;
39(13):3036-48.
PMID: 24971603
Behavioral stressors increase addiction risk in humans and increase the rewarding valence of drugs of abuse including cocaine, nicotine and ethanol in animal models. Prior studies have established that this...
26.
Groblewski P, Zietz C, Willuhn I, Phillips P, Chavkin C
Addict Biol
. 2014 Jun;
20(2):297-301.
PMID: 24919534
Cocaine-experienced Wistar and Wistar Kyoto (WKY) rats received four daily repeated forced swim stress sessions (R-FSS), each of which preceded 4-hour cocaine self-administration sessions. Twenty-four hours after the last swim...
27.
Willuhn I, Burgeno L, Groblewski P, Phillips P
Nat Neurosci
. 2014 Apr;
17(5):704-9.
PMID: 24705184
Drug addiction is a neuropsychiatric disorder marked by escalating drug use. Dopamine neurotransmission in the ventromedial striatum (VMS) mediates acute reinforcing effects of abused drugs, but with protracted use the...
28.
Simpson E, Morud J, Winiger V, Biezonski D, Zhu J, Bach M, et al.
Learn Mem
. 2014 Mar;
21(4):205-14.
PMID: 24639487
A common genetic polymorphism that results in increased activity of the dopamine regulating enzyme COMT (the COMT Val(158) allele) has been found to associate with poorer cognitive performance and increased...
29.
Hart A, Rutledge R, Glimcher P, Phillips P
J Neurosci
. 2014 Jan;
34(3):698-704.
PMID: 24431428
Making predictions about the rewards associated with environmental stimuli and updating those predictions through feedback is an essential aspect of adaptive behavior. Theorists have argued that dopamine encodes a reward...
30.
Howe M, Tierney P, Sandberg S, Phillips P, Graybiel A
Nature
. 2013 Aug;
500(7464):575-9.
PMID: 23913271
Predictions about future rewarding events have a powerful influence on behaviour. The phasic spike activity of dopamine-containing neurons, and corresponding dopamine transients in the striatum, are thought to underlie these...