Sara J McGowan
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Explore the profile of Sara J McGowan including associated specialties, affiliations and a list of published articles.
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2645
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Recent Articles
1.
Zhang L, Salekeen R, Soto-Palma C, Elsallabi O, Ye H, Hughes B, et al.
bioRxiv
. 2024 Oct;
PMID: 39463954
Cellular senescence is a key driver of the aging process and contributes to tissue dysfunction and age-related pathologies. Senolytics have emerged as a promising therapeutic intervention to extend healthspan and...
2.
Yousefzadeh M, Huerta Guevara A, Postmus A, Flores R, Sano T, Jurdzinski A, et al.
Aging Biol
. 2023 Dec;
1(1).
PMID: 38124711
Age is the greatest risk factor for the development of type 2 diabetes mellitus (T2DM). Age-related decline in organ function is attributed to the accumulation of stochastic damage, including damage...
3.
Dou Y, Darvas M, Sharma K, Mathieu J, Morton J, Tan H, et al.
Trends Biomed Res
. 2023 Apr;
3(1).
PMID: 37113577
An insulin-like growth factor-1 receptor (IGF1R) variant in exon 6 (Arg-407-His) in Ashkenazi Jewish centenarians was previously found to be associated with reduced IGF1R activity. To further study this longevity...
4.
Henpita C, Vyas R, Healy C, Kieu T, Gurkar A, Yousefzadeh M, et al.
Aging Cell
. 2023 Feb;
22(4):e13782.
PMID: 36734200
Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. Genotoxic cancer therapies are known to be potent drivers of cardiomyopathy, whereas causes of spontaneous disease remain unclear....
5.
Zhang L, Zhao J, Mu X, McGowan S, Angelini L, OKelly R, et al.
Aging Cell
. 2021 Nov;
20(12):e13486.
PMID: 34734460
Constitutive NF-κB activation is associated with cellular senescence and stem cell dysfunction and rare variants in NF-κB family members are enriched in centenarians. We recently identified a novel small molecule...
6.
Yousefzadeh M, Flores R, Zhu Y, Schmiechen Z, Brooks R, Trussoni C, et al.
Nature
. 2021 May;
594(7861):100-105.
PMID: 33981041
Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly. To define the contribution of immune system ageing to organism ageing, here we selectively...
7.
Dorronsoro A, Santiago F, Grassi D, Zhang T, Lai R, McGowan S, et al.
Aging Cell
. 2021 Mar;
20(4):e13337.
PMID: 33728821
Aging drives progressive loss of the ability of tissues to recover from stress, partly through loss of somatic stem cell function and increased senescent burden. We demonstrate that bone marrow-derived...
8.
Huerta Guevara A, McGowan S, Kazantzis M, Stallons T, Sano T, Mulder N, et al.
Metabolism
. 2021 Jan;
117:154711.
PMID: 33493548
Background: Type 2 diabetes (T2DM) is an age-associated disease characterized by hyperglycemia due to insulin resistance and decreased beta-cell function. DNA damage accumulation has been associated with T2DM, but whether...
9.
Han Y, Zhou C, Shen H, Tan J, Dong Q, Zhang L, et al.
Aging Cell
. 2020 Jun;
19(7):e13162.
PMID: 32567210
Previously, we reported that persistent DNA damage accelerates ageing of the spine, but the mechanisms behind this process are not well understood. Ataxia telangiectasia mutated (ATM) is a protein kinase...
10.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, et al.
Aging (Albany NY)
. 2020 Mar;
12(6):4688-4710.
PMID: 32201398
NF-κB is a transcription factor activated in response to inflammatory, genotoxic and oxidative stress and important for driving senescence and aging. Ataxia-telangiectasia mutated (ATM) kinase, a core component of DNA...