Paul D Dobson
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Explore the profile of Paul D Dobson including associated specialties, affiliations and a list of published articles.
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19
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733
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Recent Articles
1.
Dobson P, Coss K, Doherty C, Clifford J, Thompson B, James D
Biotechnol Bioeng
. 2020 Mar;
117(7):2295-2299.
PMID: 32181887
In cell line development the identification of stable Chinese hamster ovary cells for production is a critical but onerous task. The stability trial focus upon high-level attributes can mask profound...
2.
Stanford N, Scharm M, Dobson P, Golebiewski M, Hucka M, Kothamachu V, et al.
Methods Mol Biol
. 2019 Oct;
2049:285-314.
PMID: 31602618
Computational systems biology involves integrating heterogeneous datasets in order to generate models. These models can assist with understanding and prediction of biological phenomena. Generating datasets and integrating them into models...
3.
Strutton B, Jaffe S, Evans C, Fowler G, Dobson P, Pandhal J, et al.
Bioengineering (Basel)
. 2019 Mar;
6(1).
PMID: 30901908
strains have been modified in a variety of ways to enhance the production of different recombinant proteins, targeting membrane protein expression, proteins with disulphide bonds, and more recently, proteins which...
4.
Swainston N, Batista-Navarro R, Carbonell P, Dobson P, Dunstan M, Jervis A, et al.
PLoS One
. 2017 Jul;
12(7):e0179130.
PMID: 28708831
Biologists and biochemists have at their disposal a number of excellent, publicly available data resources such as UniProt, KEGG, and NCBI Taxonomy, which catalogue biological entities. Despite the usefulness of...
5.
Swainston N, Smallbone K, Hefzi H, Dobson P, Brewer J, Hanscho M, et al.
Metabolomics
. 2016 Jul;
12:109.
PMID: 27358602
Introduction: The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes. Capturing the whole human metabolic...
6.
Kell D, Dobson P, Bilsland E, Oliver S
Drug Discov Today
. 2012 Dec;
18(5-6):218-39.
PMID: 23207804
A recent paper in this journal sought to counter evidence for the role of transport proteins in effecting drug uptake into cells, and questions that transporters can recognize drug molecules...
7.
Lanthaler K, Bilsland E, Dobson P, Moss H, Pir P, Kell D, et al.
BMC Biol
. 2011 Oct;
9:70.
PMID: 22023736
Background: The uptake of drugs into cells has traditionally been considered to be predominantly via passive diffusion through the bilayer portion of the cell membrane. The recent recognition that drug...
8.
Nobata C, Dobson P, Iqbal S, Mendes P, Tsujii J, Kell D, et al.
Metabolomics
. 2011 Jun;
7(1):94-101.
PMID: 21687783
Text mining methods have added considerably to our capacity to extract biological knowledge from the literature. Recently the field of systems biology has begun to model and simulate metabolic networks,...
9.
Kell D, Dobson P, Oliver S
Drug Discov Today
. 2011 Jun;
16(15-16):704-14.
PMID: 21624498
All cells necessarily contain tens, if not hundreds, of carriers for nutrients and intermediary metabolites, and the human genome codes for more than 1000 carriers of various kinds. Here, we...
10.
Dobson P, Smallbone K, Jameson D, Simeonidis E, Lanthaler K, Pir P, et al.
BMC Syst Biol
. 2010 Oct;
4:145.
PMID: 21029416
Background: To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven reconstruction, while...