Paul D Chastain 2nd
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Explore the profile of Paul D Chastain 2nd including associated specialties, affiliations and a list of published articles.
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20
Citations
612
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Recent Articles
1.
Duan L, Perez R, Chastain 2nd P, Mathew M, Bijukumar D, Maki C
Oncogene
. 2019 Apr;
38(28):5643-5657.
PMID: 30967636
Platinum-based drugs such as cisplatin (CP) are the first-line chemotherapy for non-small-cell lung carcinoma (NSCLC). Unfortunately, NSCLC has a low response rate to CP and acquired resistance always occurs. Histone...
2.
Smith-Roe S, Nakamura J, Holley D, Chastain 2nd P, Rosson G, Simpson D, et al.
Oncotarget
. 2014 Dec;
6(2):732-45.
PMID: 25544751
SWI/SNF complexes utilize BRG1 (also known as SMARCA4) or BRM (also known as SMARCA2) as alternative catalytic subunits with ATPase activity to remodel chromatin. These chromatin-remodeling complexes are required for...
3.
Chastain 2nd P, Brylawski B, Zhou Y, Rao S, Chu H, Ibrahim J, et al.
Photochem Photobiol
. 2014 Oct;
91(1):109-16.
PMID: 25316620
We investigated the hypothesis that the strength of the activation of the intra-S DNA damage checkpoint varies within the S phase. Synchronized diploid human fibroblasts were exposed to either 0...
4.
Prasad R, Horton J, Chastain 2nd P, Gassman N, Freudenthal B, Hou E, et al.
Nucleic Acids Res
. 2014 Apr;
42(10):6337-51.
PMID: 24771347
Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD(+) and plays multifaceted roles in cellular responses to genotoxic...
5.
Stewart J, Wang F, Chaiken M, Kasbek C, Chastain 2nd P, Wright W, et al.
EMBO J
. 2012 Aug;
31(17):3537-49.
PMID: 22863775
Mammalian CST (CTC1-STN1-TEN1) associates with telomeres and depletion of CTC1 or STN1 causes telomere defects. However, the function of mammalian CST remains poorly understood. We show here that depletion of...
6.
Cohen S, Chastain 2nd P, Rosson G, Groh B, Weissman B, Kaufman D, et al.
Nucleic Acids Res
. 2010 Jun;
38(20):6906-19.
PMID: 20571081
For DNA replication to occur, chromatin must be remodeled. Yet, we know very little about which proteins alter nucleosome occupancy at origins and replication forks and for what aspects of...
7.
Chastain 2nd P, Nakamura J, Rao S, Chu H, Ibrahim J, Swenberg J, et al.
FASEB J
. 2010 Jun;
24(10):3674-80.
PMID: 20511393
We investigated whether apurinic/apyrimidinic (AP/abasic) sites were more frequent in regions of DNA replication in cells and whether their number increased during oxidative stress. DNA fiber spreading and fluorescent immunostaining...
8.
Asagoshi K, Tano K, Chastain 2nd P, Adachi N, Sonoda E, Kikuchi K, et al.
Mol Cancer Res
. 2010 Feb;
8(2):204-15.
PMID: 20145043
From in vitro studies, flap endonuclease 1 (FEN1) has been proposed to play a role in the long patch (LP) base excision repair (BER) subpathway. Yet the role of FEN1...
9.
Cohen S, Chastain 2nd P, Cordeiro-Stone M, Kaufman D
Epigenetics Chromatin
. 2009 May;
2(1):6.
PMID: 19442263
Background: The GINS complex is thought to be essential for the processes of initiation and elongation of DNA replication. This complex contains four subunits, one of which (Psf1) is proposed...
10.
Dorn E, Chastain 2nd P, Hall J, Cook J
Nucleic Acids Res
. 2008 Nov;
37(1):60-9.
PMID: 19010964
A major challenge each human cell-division cycle is to ensure that DNA replication origins do not initiate more than once, a phenomenon known as re-replication. Acute deregulation of replication control...