Paul C Megee
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Explore the profile of Paul C Megee including associated specialties, affiliations and a list of published articles.
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11
Citations
897
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Recent Articles
1.
Megee P, Uhley V, Grogan J, Silverman A
MedEdPORTAL
. 2024 Apr;
20:11397.
PMID: 38595707
Introduction: Foundational and clinical science integration, a long-standing goal of undergraduate medical education, benefits learners by promoting retention of critical knowledge and skills as well as their transfer to the...
2.
Woodman J, Hoffman M, Dzieciatkowska M, Hansen K, Megee P
Mol Biol Cell
. 2015 Sep;
26(21):3754-67.
PMID: 26354421
The cohesion of replicated sister chromatids promotes chromosome biorientation, gene regulation, DNA repair, and chromosome condensation. Cohesion is mediated by cohesin, which is deposited on chromosomes by a separate conserved...
3.
Kline A, Calof A, Lander A, Gerton J, Krantz I, Dorsett D, et al.
Am J Med Genet A
. 2015 Apr;
167(6):1179-92.
PMID: 25899772
Cornelia de Lange Syndrome (CdLS) is the most common example of disorders of the cohesin complex, or cohesinopathies. There are a myriad of clinical issues facing individuals with CdLS, particularly...
4.
Woodman J, Fara T, Dzieciatkowska M, Trejo M, Luong N, Hansen K, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(19):7060-5.
PMID: 24778232
Sister chromatid cohesion (SCC), efficient DNA repair, and the regulation of some metazoan genes require the association of cohesins with chromosomes. Cohesins are deposited by a conserved heterodimeric loading complex...
5.
Kim H, Erickson B, Luo W, Seward D, Graber J, Pollock D, et al.
Nat Struct Mol Biol
. 2010 Sep;
17(10):1279-86.
PMID: 20835241
Phosphorylation of the RNA polymerase (Pol) II C-terminal domain (CTD) repeats (1-YSPTSPS-7) is coupled to transcription and may act as a 'code' that controls mRNA synthesis and processing. To examine...
6.
Kogut I, Wang J, Guacci V, Mistry R, Megee P
Genes Dev
. 2009 Oct;
23(19):2345-57.
PMID: 19797771
Cohesins mediate sister chromatid cohesion and DNA repair and also function in gene regulation. Chromosomal cohesins are distributed nonrandomly, and their deposition requires the heterodimeric Scc2/Scc4 loader. Whether Scc2/Scc4 establishes...
7.
Eckert C, Gravdahl D, Megee P
Genes Dev
. 2007 Jan;
21(3):278-91.
PMID: 17242156
Sister chromatid cohesion, conferred by the evolutionarily conserved cohesin complex, is essential for proper chromosome segregation. Cohesin binds to discrete sites along chromosome arms, and is especially enriched surrounding centromeres,...
8.
Kiburz B, Reynolds D, Megee P, Marston A, Lee B, Lee T, et al.
Genes Dev
. 2005 Dec;
19(24):3017-30.
PMID: 16357219
The stepwise loss of cohesins, the complexes that hold sister chromatids together, is required for faithful meiotic chromosome segregation. Cohesins are removed from chromosome arms during meiosis I but are...
9.
Glynn E, Megee P, Yu H, Mistrot C, Unal E, Koshland D, et al.
PLoS Biol
. 2004 Aug;
2(9):E259.
PMID: 15309048
In eukaryotic cells, cohesin holds sister chromatids together until they separate into daughter cells during mitosis. We have used chromatin immunoprecipitation coupled with microarray analysis (ChIP chip) to produce a...
10.
Weber S, Gerton J, Polancic J, DeRisi J, Koshland D, Megee P
PLoS Biol
. 2004 Aug;
2(9):E260.
PMID: 15309047
The recruitment of cohesins to pericentric chromatin in some organisms appears to require heterochromatin associated with repetitive DNA. However, neocentromeres and budding yeast centromeres lack flanking repetitive DNA, indicating that...