Paul Brear
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Explore the profile of Paul Brear including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
258
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Recent Articles
1.
Wang M, Medarametla P, Kronenberger T, Deingruber T, Brear P, Figueroa W, et al.
Nat Commun
. 2025 Mar;
16(1):2334.
PMID: 40057486
Fatty acids are a primary source of carbon for Pseudomonas aeruginosa (PA) in the airways of people with cystic fibrosis (CF). Here, we use tandem mass-tag proteomics to analyse the...
2.
Wijaya A, Dolan S, Kohlstedt M, Glaser L, Brear P, Geddis S, et al.
J Biol Chem
. 2025 Feb;
:108355.
PMID: 40015638
The 2-methylcitrate cycle (2-MCC) and the glyoxylate cycle are central metabolic pathways in Pseudomonas aeruginosa, enabling the organism to utilize organic acids such as propionate and acetate during infection. Here,...
3.
McQuail J, Krepl M, Katsuya-Gaviria K, Tabib-Salazar A, Burchell L, Bischler T, et al.
Nucleic Acids Res
. 2025 Jan;
53(3).
PMID: 39868539
The RNA chaperone Hfq plays crucial roles in bacterial gene expression and is a major facilitator of small regulatory RNA (sRNA) action. The toroidal architecture of the Hfq hexamer presents...
4.
Fischer K, Lulla A, So T, Pereyra-Gerber P, Raybould M, Kohler T, et al.
Nat Biotechnol
. 2024 Aug;
PMID: 39143416
Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of...
5.
Reinecke M, Brear P, Vornholz L, Berger B, Seefried F, Wilhelm S, et al.
Nat Chem Biol
. 2023 Oct;
20(5):577-585.
PMID: 37904048
Medicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical probes to study kinase biology. Because of polypharmacology, a...
6.
Harman M, Stanway S, Scott H, Demydchuk Y, Bezerra G, Pellegrino S, et al.
J Med Chem
. 2023 Jul;
66(14):9881-9893.
PMID: 37433017
Angiotensin-converting enzyme 2 (ACE2) is a metalloprotease that cleaves angiotensin II, a peptide substrate involved in the regulation of hypertension. Here, we identified a series of constrained bicyclic peptides, ,...
7.
Gaynor K, Vaysburd M, Harman M, Albecka A, Jeffrey P, Beswick P, et al.
Nat Commun
. 2023 Jun;
14(1):3583.
PMID: 37328472
COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of...
8.
Sonnleitner E, Bassani F, Cianciulli Sesso A, Brear P, Lilic B, Davidovski L, et al.
Front Microbiol
. 2023 May;
14:1195558.
PMID: 37250041
In the opportunistic human pathogen (), arbon atabolite epression (CCR) orchestrates the hierarchical utilization of N and C sources, and impacts virulence, antibiotic resistance and biofilm development. During CCR, the...
9.
Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture
Knyphausen P, Rangel Pereira M, Brear P, Hyvonen M, Jermutus L, Hollfelder F
Nat Commun
. 2023 Feb;
14(1):768.
PMID: 36765057
Tailoring of the activity and specificity of proteases is critical for their utility across industrial, medical and research purposes. However, engineering or evolving protease catalysts is challenging and often labour...
10.
Nain-Perez A, Nilsson O, Lulla A, Haversen L, Brear P, Liljenberg S, et al.
Eur J Med Chem
. 2023 Feb;
250:115177.
PMID: 36753880
The liver isoform of pyruvate kinase (PKL) has gained interest due to its potential capacity to regulate fatty acid synthesis involved in the progression of non-alcoholic fatty liver disease (NAFLD)....