Paul A Welling
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Explore the profile of Paul A Welling including associated specialties, affiliations and a list of published articles.
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92
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2482
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Recent Articles
1.
Wu A, Wolley M, Vesey D, Terker A, Welling P, Fenton R, et al.
Nephrology (Carlton)
. 2025 Mar;
30(3):e70017.
PMID: 40084744
Aim: Using urinary extracellular vesicles (uEVs), we have demonstrated the functional 'renal-K switch' mechanism (the WNK-SPAK-NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between...
2.
Bernard L, Yang J, Chen J, Sullivan V, Yu B, Rhee E, et al.
Clin J Am Soc Nephrol
. 2025 Mar;
PMID: 40067387
Background: Discovering metabolomic markers of dietary potassium may help improve dietary assessment of potassium and trace the impact of dietary potassium on chronic kidney disease (CKD) development. Methods: We included...
3.
Trumbo P, Glass K, Lee S, Moshfegh A, Welling P, Zecca P
J Food Sci
. 2024 Sep;
89(10):6086-6097.
PMID: 39289814
Most Americans exceed the recommended limit for sodium in their diet, a risk factor for hypertension and cardiovascular disease. Efforts have been made by the food industry and government agencies...
4.
Nguyen N, Sheng S, Banerjee A, Guerriero C, Chen J, Wang X, et al.
Mol Biol Cell
. 2024 Jul;
35(9):ar119.
PMID: 39024255
Hypertension affects one billion people worldwide and is the most common risk factor for cardiovascular disease, yet a comprehensive picture of its underlying genetic factors is incomplete. Amongst regulators of...
5.
Ferdaus M, Terker A, Koumangoye R, Al-Qusairi L, Welling P, Delpire E
Am J Physiol Renal Physiol
. 2024 Jul;
327(3):F373-F385.
PMID: 38961847
Dietary potassium deficiency causes stimulation of sodium reabsorption leading to an increased risk in blood pressure elevation. The distal convoluted tubule (DCT) is the main rheostat linking plasma K levels...
6.
Jung H, Pham T, Su X, Grigore T, Hoenderop J, Olauson H, et al.
Sci Rep
. 2024 May;
14(1):10740.
PMID: 38729987
Klotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief...
7.
Welling P, Little R, Al-Qusairi L, Delpire E, Ellison D, Fenton R, et al.
Hypertension
. 2024 Mar;
81(5):1044-1054.
PMID: 38465625
Background: Potassium (K)-deficient diets, typical of modern processed foods, increase blood pressure (BP) and NaCl sensitivity. A K-dependent signaling pathway in the kidney distal convoluted tubule, coined the K switch,...
8.
Ferdaus M, Koumangoye R, Welling P, Delpire E
Hypertension
. 2024 Jan;
81(4):801-810.
PMID: 38258567
Background: Potassium regulates the WNK (with no lysine kinase)-SPAK (STE20/SPS1-related proline/alanine-rich kinase) signaling axis, which in turn controls the phosphorylation and activation of the distal convoluted tubule thiazide-sensitive NCC (sodium-chloride...
9.
Su X, Reyes J, Lackey A, Demirci H, Bachmann S, Maeoka Y, et al.
J Am Soc Nephrol
. 2024 Jan;
35(4):426-440.
PMID: 38238903
Significance Statement: High-resolution single-nucleus RNA-sequencing data indicate a clear separation between primary sites of calcium and magnesium handling within distal convoluted tubule (DCT). Both DCT1 and DCT2 express Slc12a3, but...
10.
Gharaie S, Lee K, Noller K, Lo E, Miller B, Jung H, et al.
Sci Rep
. 2023 Nov;
13(1):20888.
PMID: 38017015
T cells are important in the pathogenesis of acute kidney injury (AKI), and TCRCD4CD8 (double negative-DN) are T cells that have regulatory properties. However, there is limited information on DN...