Paul A B Moretti
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Explore the profile of Paul A B Moretti including associated specialties, affiliations and a list of published articles.
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23
Citations
934
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Recent Articles
1.
Lewis A, Pope V, Tea M, Li M, Nwosu G, Nguyen T, et al.
Blood
. 2022 Apr;
139(26):3737-3751.
PMID: 35443029
Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly defined. In this study, triggering an accumulation of ceramide in acute myeloid...
2.
Tvorogov D, Thompson-Peach C, Fosselteder J, Dottore M, Stomski F, Onnesha S, et al.
EMBO Rep
. 2022 Feb;
23(4):e52904.
PMID: 35156745
Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope potentially targetable by immunotherapeutic approaches. We developed a specific rat...
3.
Pitman M, Lewis A, Davies L, Moretti P, Anderson D, Creek D, et al.
Sci Rep
. 2022 Jan;
12(1):454.
PMID: 35013382
Sphingosine 1-phosphate (S1P) is a signaling lipid that has broad roles, working either intracellularly through various protein targets, or extracellularly via a family of five G-protein coupled receptors Agents that...
4.
Powell J, Pitman M, Zebol J, Moretti P, Neubauer H, Davies L, et al.
Biochem J
. 2019 Oct;
476(21):3211-3226.
PMID: 31652307
Sphingosine kinase 1 (SK1) is a signalling enzyme that catalyses the phosphorylation of sphingosine to generate the bioactive lipid sphingosine 1-phosphate (S1P). A number of SK1 inhibitors and chemotherapeutics can...
5.
Neubauer H, Tea M, Zebol J, Gliddon B, Stefanidis C, Moretti P, et al.
Oncogene
. 2018 Sep;
38(8):1151-1165.
PMID: 30250299
While the two mammalian sphingosine kinases, SK1 and SK2, both catalyze the generation of pro-survival sphingosine 1-phosphate (S1P), their roles vary dependent on their different subcellular localization. SK1 is generally...
6.
Zhu W, Jarman K, Lokman N, Neubauer H, Davies L, Gliddon B, et al.
Cancer Res
. 2017 Jul;
77(18):4823-4834.
PMID: 28729416
Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogenic signaling by SK1 relies on its localization to the plasma membrane, which...
7.
Wallington-Beddoe C, Bennett M, Vandyke K, Davies L, Zebol J, Moretti P, et al.
Oncotarget
. 2017 May;
8(27):43602-43616.
PMID: 28467788
The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production of malignant plasma cells, bortezomib induces endoplasmic reticulum...
8.
Powell J, Lewis A, Zhu W, Toubia J, Pitman M, Wallington-Beddoe C, et al.
Blood
. 2016 Dec;
129(6):771-782.
PMID: 27956387
Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in conventional chemotherapy and bone marrow transplantation, overall survival remains poor. Sphingosine kinase 1 (SPHK1) generates the bioactive lipid...
9.
Neubauer H, Pham D, Zebol J, Moretti P, Peterson A, Leclercq T, et al.
Oncotarget
. 2016 Sep;
7(40):64886-64899.
PMID: 27588496
While both human sphingosine kinases (SK1 and SK2) catalyze the generation of the pleiotropic signaling lipid sphingosine 1-phosphate, these enzymes appear to be functionally distinct. SK1 has well described roles...
10.
Pitman M, Powell J, Coolen C, Moretti P, Zebol J, Pham D, et al.
Oncotarget
. 2015 Mar;
6(9):7065-83.
PMID: 25788259
The dynamic balance of cellular sphingolipids, the sphingolipid rheostat, is an important determinant of cell fate, and is commonly deregulated in cancer. Sphingosine 1-phosphate is a signaling molecule with anti-apoptotic,...